Item | Information |
---|---|
CAS RN | 105779-78-0 |
Chemical Name | 5-Chloro-N-{2-[4-(2-ethoxyethyl)-2,3-dimethylphenoxy]ethyl}-6-ethylpyrimidine-4-amine; Pylimidifen |
Substance ID | m-nite-105779-78-0_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | Not classified |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 3. [Evidence Data] (1) LD50 for rats: male: 148 mg/kg, female: 115 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), Japanese Journal of Pesticide Science vol. 24 No. 2 (Japan Crop Protection Association, 1999)) (2) LD50 for rats: 115-148 mg/kg (Food Sanitation Research vol. 48 No.11 (Japan Crop Protection Association, 1998)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), Japanese Journal of Pesticide Science vol. 24 No. 2 (Japan Crop Protection Association, 1999)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 2. [Evidence Data] (1) LC50 (4 hours) for rats: male: 0.069 mg/L, female: 0.076 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) No irritation was observed in a skin irritation test with rabbits (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) No irritation was observed in a skin irritation test in which this substance (0.5 g) was applied to rabbits (Japanese Journal of Pesticide Science vol. 24 No. 2 (Japan Crop Protection Association, 1999)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 2B. [Evidence Data] (1) Slight irritation was observed in an eye irritation test with rabbits (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) Transient conjunctival inflammation was observed in an eye irritation test in which this substance (46 mg) was applied to the eyes of rabbits, however, it resolved within 3 days (Japanese Journal of Pesticide Science vol. 24 No. 2 (Japan Crop Protection Association, 1999)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 1. [Evidence Data] (1) Moderate sensitization was observed in a skin sensitization test (maximization method) with guinea pigs (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). [Reference Data, etc.] (2) No sensitization was observed in a skin sensitization test (Buehler method) with guinea pigs (Japanese Journal of Pesticide Science vol. 24 No. 2 (Japan Crop Protection Association, 1999), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), since the results of all standard combination tests, were negative, it was classified as "Not classified." [Evidence Data] (1) As for in vivo, there was a report of a negative result in a micronucleus test with mice (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) As for in vitro, there were reports on negative results in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (Japanese Journal of Pesticide Science vol. 24 No. 2 (Japan Crop Protection Association, 1999), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] There were no classification results by domestic and international organizations. There are no reports for humans available. Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) In a combined chronic toxicity/carcinogenicity study in which rats were given this substance by feeding for 2 years, a significant increase in benign pheochromocytomas of the adrenal gland was observed in males at 100 ppm. In females, the incidence of pheochromocytomas of the adrenal gland was low even in the treated groups, and there was no difference from the control group (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) In a carcinogenicity test in which mice were given this substance by feeding for 86 weeks, no increases in the incidence of neoplastic lesions were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified." [Evidence Data] (1) In a 2-generation reproductive toxicity test with rats dosed by feeding, reduced body weight gain, reduced food consumption and increased liver weight were observed in the parent animals of P and F1, and decreased spermatogenesis were observed in the F1 parental animals, but no reproductive effects were observed. Reduced body weight gain and lower body weight in the F1 and F2 pups and delayed preputial separation and delayed vaginal opening in the F1 pups were observed at the same doses where parental toxicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) In a developmental toxicity test with female rats dosed by gavage on gestational Days 6-15, lower body weight, delayed ossification (sternebrae) and skeletal variations (14th ribs) were observed in the fetuses at the dose where maternal toxicity (decreased body weight gain, decreased food consumption) was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (3) In a developmental toxicity test with female rabbits dosed by gavage on gestational Days 6-19, delayed ossification (carpal bones, metacarpals, and phalanges) was observed in fetuses at the dose where maternal toxicity (emergency slaughter (1 out of 15-16 animals), reduced body weight gain, reduced food consumption) was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. Target organs could not be identified from the symptoms in the oral test in (1), and the symptoms in the inhalation test in (2) were observed in the vicinity of lethal doses, and none of these were judged to be appropriate as evidence of the classification. Since the previous classification result was based on these symptoms, the classification result was changed. [Reference Data, etc.] (1) In single oral administration tests with rats and mice, inactivity and bradypnea were observed. Deaths were observed at or above 35 mg/kg (male and female) in rats and at or above 204 mg/kg (male) or 120 mg/kg (female) in mice (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) In a single inhalation exposure test (no description of the exposure time, but 4 hours) with rats, partial eye closure, decreased respiratory rate, exertional respiration and mouth opening during inspiration were observed. Deaths occurred at or above 0.068 mg/L (male and female) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system, kidney) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1 (blood system, kidney). As a result of reviewing by the use of new information sources, the classification result was changed from the previous classification. Besides, the liver was not adopted as a target organ since the findings were considered to be adaptive changes. [Evidence Data] (1) In a 90-day repeated dose toxicity test with rats dosed by feeding, reduced body weight gain and decreased hemoglobin level in males and females, increased urea nitrogen and creatinine and increased kidney weight in males, and decreased erythrocyte counts, etc. in females were observed at 150 ppm (male/female: 8.74/9.43 mg/kg/day, within the range of Category 1) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) In a 90-day repeated dose toxicity test with mice dosed by feeding, increased liver and kidney weights were observed in females at 100 ppm (male/female: 13.4/17.7 mg/kg/day, within the range of Category 2), and at 300 ppm (male/female: 39.7/46.7 mg/kg/day, within the range of Category 2), centrilobular hepatocellular hypertrophy in males and females, increased liver weight in males, and decreased hemoglobin level and erythrocyte counts, and increased urea nitrogen, etc. in females were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (3) In a combined chronic toxicity/carcinogenicity study with rats dosed by feeding for 2 years, reduced body weight gain, increased urea nitrogen and increased epithelial brown pigmentation of the renal tubules were observed in females at 100 ppm (male/female: 3.41/4.47 mg/kg/day, within the range of Category 1) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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