Item | Information |
---|---|
CAS RN | 111-27-3 |
Chemical Name | hexan-1-ol |
Substance ID | m-nite-111-27-3_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
If the flash point is 60degC or lower, the substance fits in Category 3, and if above 60degC, fits in Category 4. The flash points are 58.4degC (Closed Cup, HSDB (2006)), and 63degC (Closed Cup, Merck (14th, 2006), HSDB (2006)), and the compound fits in UNRTDG Class 3, Packing group III. Thus, the substance was classified into Category 3 based on the rating. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Since its autoignition points are 290 - 304degC (HSDB (2006), ICSC (J) (2002), NFPA (13th, 2006)), the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | In rat LD50 studies, a study provided a value that was equivalent to the guidance value of Category 4 (LD50 = 1800 mg/kg (male), 720 mg/kg (female) (DFGOT vol. 9, (1998))), and four studies provided values that were equivalent to the guidance values of "Not classified" (LD50 = 4000 mg/kg, 4590 mg/kg, 4870 mg/kg, 7080 mg/kg (DFGOT vol. 9, (1998))). Thus, the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on its rabbit LD50 value of 2538 mg/kg (DFGOT vol. 9, 1998; PATTY 5th, 2001), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in UN classification). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | A single 8-hour exposure to air practically saturated with the substance at 20degC (saturated vapour pressure concentration at 20degC (approximately 5.6 mg/L)) (4-hour conversion, approximately 8 mg/L) was "not lethal" for rats (DFGOT vol. 9, 1998). However, the results provide insufficient data, and thus, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | In a 1-hour inhalation test using rats, the LC50 was more than 21 mg/L (4-hour conversion LC50 > 10.5 mg/L, IUCLID 2000). Thus, the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
In a human patch test, the substance was applied to the skin for up to four hours. The irritation response was significantly lower than that of the positive control (PATTY (5th, 2001)). In a rabbit test compliant with OECD TG 404, the substance was indicated to be "moderately irritating" (IUCLID (2000)). With unknown doses and administration periods, the substance caused "moderate irritation" (DFGOT vol. 9 (1998) and "erythema and swelling like a first degree burn" (DFGOT vol. 9 (1998). Based on these results, the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
In a rabbit test, the averaged score values 72 hours after application were 2 for corneal clouding, 1.25 for iritis, 2.5 for conjunctival redness, and 2.5 for chemosis, but these signs completely subsided within 21 days after application (ECETOC TR. 48 (1998)). In a rabbit test (OECD TG 405), the substance was considered to be moderately irritating (IUCLID (2000)), and in another rabbit test, a 5% solution caused severe eye erosion while a 1% solution still caused severe irritation (DFGOT vol. 9, 1998). Based on these results, the substance was classified into Category 2A. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Not classified |
- |
- | - | Based on the description that no sensitization was observed in a human patch test or an allergic test in guinea pigs (according to the method of Magnusson and Kligman) (DFGOT vol. 9, 1998), the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Because in vivo mutagenicity test data on this substance are lacking (DFGOT vol. 2 (1998), IUCLID (2000)), the substance was classified into "Classification not possible". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | As for its developmental toxicity, oral administration to rats during the organogenetic period caused clinical signs and decreased body weight gains in parental animals, but no embryotoxic or teratogenic effects were observed (PATTY 5th, 2001). However, the study did not provide data on sexual functions or fertility of parental animals, and thus, the substance was classified into "Classification not possible". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | It is documented that rats were given the substance of 440 mg/kg (for males) and 90 mg/kg (for females) by gavage, and the renal cortex was hyperaemic with cloudy swelling (DFGOT vol. 9, 1998). However, this report lacks detailed data, and the substance was classified into "Classification not possible". As relevant information, a mixture containing this substance was used in an inhalation test using rats, mice, and guinea pigs, and in a skin test using rabbits. In the inhalation test, the mixture containing the substance was associated with respiratory irritation. However, the purity of the substance was as low as 44% (44% 1-hexanol, 53% methyl-1-pentanol), and the finding was not used for classification. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a test in which rats were fed a diet containing the substance for three weeks (PATTY 5th (2001)), a dose of 330 mg/kg bw (converted for 90 days), that was over the guidance range, showed no effect other than minimal changes such as the blood lipid level. In addition, in a test in which rats were fed a diet containing the substance for 13 weeks (IUCLID (2000)), doses that were over the guidance range resulted in NOAEL of 250 mg/kg bw and LOAEL of 500 mg/kg bw. These doses would be equivalent to the guidance values of "Not classified" (oral). However, since no data of other administration routes is available, the substance was classified into "Classification not possible". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | It is documented that aspiration of 0.2 mL of the substance caused deaths in 10 out of 10 rats, and that the deaths were instantaneous due to respiratory arrest (PATTY 5th, 2001; IUCLID, 2000). However, since the description is old and it does not provide sufficient information for classifying the substance into "Not classified" (Category 2 in UN classification), the substance was classified into "Classification not possible". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
Since its 96 h-LC50 = 97.7 mg/L for fish (fathead minnow) (AQUIRE, 2008), the substance was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
Since its preexisting classification for acute toxicity is Category 3 and it lacks reliable rapid degradability data, the substance was classified into Category 3. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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