Item | Information |
---|---|
CAS RN | 124-43-6 |
Chemical Name | Hydrogen peroxide--urea |
Substance ID | m-nite-124-43-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties (neighboring oxygen atoms) present in the molecule, and the calculated oxygen balance is -34, higher than the criteria: -200. However, because it is classified in Division 5.1 (Subsidiary Risk 8), PG III in UNRTDG (UN1511), it does not correspond to explosives, hazards of the highest precedence, and it was classified as "Not classified." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | It was classified as "Not classified (Not applicable)" because it was classified as oxidizing solids. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Because it is classified in Division 5.1 (Subsidiary Risk 8), PG III in UNRTDG (UN1511), it does not correspond to pyrophoric substances, hazards of the highest precedence, and it was classified as "Not classified." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Category 3 |
Warning |
H272 | P370+P378 P210 P220 P280 P501 |
It was classified in Category 3 because it is classified in Division 5.1 (Subsidiary Risk 8), PG III in UNRTDG (UN1511). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | There is a bivalent -O-O- structure present in the molecule, but it is hydrogen peroxide, not an organic compound. Therefore, it was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | Not classified |
- |
- | - | It was classified as "Not classified" because it is not desensitized by wetting, dilution, etc. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: female: >2,000 mg/kg (REACH registration dossier(Access on December 2019)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
[Rationale for the Classification] Based on (1), this substance was determined to be corrosive (Category 1) or irritant (Category 2). On the other hand, based on (2), corrosiveness was denied. Therefore, it was classified in Category 2. The category was changed due to new data obtained. [Evidence Data] (1) In an in vitro skin irritation test using an artificial skin model according to the OECD TG 439, the mean value of relative tissue viability was 4.1% after exposure for 60 minutes, and it was determined to be corrosive (Category 1) or irritant (Category 2) (REACH registration dossier (Access on December 2019)). (2) In an in vitro skin corrosive test using an artificial skin model according to the OECD TG 431, the mean values of relative tissue viability after 3-minute and 60-minute exposure were 72.8% and 19.3%, respectively, and corrosiveness was denied (REACH registration dossier (Access on December 2019)). [Reference Data, etc.] (3) This substance was classified as "Skin irrit. 2 (H315)" in the EU-CLP classification (EU CLP classification (Access on December 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] Based on (1), it was classified in Category 1. [Evidence Data] (1) In an in vitro bovine corneal opacity and permeability (BCOP) test according to OECD TG 437, the in vitro irritancy score (IVIS) was 99.44. Therefore, it was determined to correspond to Category 1 (REACH registration dossier (Access on December 2019)). [Reference Data, etc.] (2) This substance was classified as "Eye Irrt. 2 (H319)" in the EU CLP classification (EU CLP classification (Access on December 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified." [Evidence Data] (1) From the results of patch tests on approximately 30,000 patients, including hairdressers and allergic dermatitis patients, hydrogen peroxide, a hydrolysis product of this substance, was determined not to be a skin sensitiser (REACH registration dossier (Accessed on December 2019)). (2) In a human patch test on volunteers, urea, a hydrolysis product of this substance was determined not to be a skin sensitiser (REACH registration dossier (Accessed on December 2019)). (3) This substance decomposes on contact with water to hydrogen peroxide and urea. However, both substances lack a skin sensitising potential. Therefore, this substance was considered not to be a skin sensitiser (REACH registration dossier (Access on December 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There is no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, it is reported that this substance was positive in a bacterial reverse mutation test (NTP DB (Access on October 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. There were reports in experimental animals in (1) and (2). However, this information was considered to be insufficient to determine a target organ. Also, information on the respiratory tract irritation in the previous classification was not adopted because it was from the information source in List 3. Therefore, the classification result was changed. [Reference Data, etc.] (1) In a single oral administration test with rats, at 2,000 mg/kg, sedation, apathy, piloerection, hunched posture and closed eyes were observed immediately after administration up to 6 hours later. However, these were fully resolved. No mortalities occurred, and there were no necropsy findings (REACH registration dossier (Access on December 2019)). (2) In another single oral administration test with rats, gastric ulceration was observed in all treated groups at necropsy 1 hour after administration of 5, 15, and 50 mg/kg. At necropsy after 24 hours, the gastric ulceration was absent in the dose group at 5 mg/kg and was diminished in the 15 and 50 mg/kg groups (REACH registration dossier (Access on December 2019)). (3) This substance is dissolved in water to form hydrogen peroxide (CAS RN 7722-84-1) and urea (CAS RN 57-13-6) (REACH registration dossier (Access on December 2019)). There is a description that in humans, exposure to high concentrations of the vapor or the mist of hydrogen peroxide had caused irritation and inflammation in the nose and throat (ACGIH (7th, 2001)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) This substance was dissolved in water to form hydrogen peroxide (CAS RN 7722-84-1) and urea (CAS RN 57-13-6). Inhalation toxicity caused by hydrogen peroxide is considered to be the main toxicity (REACH registration dossier (Access on December 2019)). (2) In the GHS classification result in FY 2013, hydrogen peroxide was classified in Category 1 (respiratory organs) based on the following: There is a description that in inhalation tests with dogs and rats using hydrogen peroxide, at concentrations (0.005-0.01 mg/L) within the guidance value range for Category 1, fibrotic lesions were scattered in the lungs, and patchy areas of atelectasis and emphysema in the lungs (dogs) and necrosis and inflammation of the nasal cavity epithelium, cellular infiltration in the larynx (rats) were observed (EU-RAR (2003)). Also, there is a description that in humans, irritation in the nose and throat was observed, and there was a risk of pulmonary edema in the worst case (ECETOC JACC (1993)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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