Item | Information |
---|---|
CAS RN | 1569-02-4 |
Chemical Name | Propylene glycol monoethyl ether; 1-Ethoxy-2-propanol |
Substance ID | m-nite-1569-02-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 3 based on flash point data of 40 deg C (closed cup) (ICSC (2004)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from an autoignition temperature of 255 deg C (ICSC (2004)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to low-temperature-boiling liquids are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | Not classified |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1)-(3), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: >2,000 mg/kg, >4,400 mg/kg, >=5,000 mg/kg (ACGIH (7th, 2019)) (2) LD50 for rats: 4,500 mg/kg (ECETOC TR95 (2005)) (3) LD50 for rats: >5,000 mg/kg (PATTY (6th, 2012)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rabbits: 8,100 mg/kg (ACGIH (7th, 2019), PATTY (6th, 2012), ECETOC TR95 (2005)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1), since there were no deaths by exposure to this substance, the LC50 was considered to be higher than 2,213 ppm, but the category could not be determined. Therefore, it was classified as "Classification not possible." Besides, the exposure concentrations were lower than 90% of the saturated vapor pressure concentration (5,079.3 ppm), so the reference values in units of ppm were applied as vapour with little mist. [Evidence Data] (1) Inhalation in rats (4 hours): no mortality at 3,337 ppm (whole-body exposure), 2,213 ppm (nose-only exposure) (ACGIH (7th, 2019), PATTY (6th, 2012)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." Besides, since the exposure concentration was higher than 90% of the saturated vapor pressure concentration (5,079.3 ppm), a reference value in unit of mg/L was applied as a mist. [Evidence Data] (1) Inhalation in rats (4 hours): no mortality at 1,420 mg/L (ACGIH (7th, 2019)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) In a skin irritation test with rabbits equivalent or similar to OECD TG 404, slight erythema was observed at 1 and 24 hours after exposure and disappeared after 48 hours. Flaking was also noted, but it disappeared within 7 days. The mean scores for erythema and edema at 24/48/72 hours were 0-1.33 and 0, respectively (REACH registration dossier (Access on August, 2019)). [Reference Data, etc.] (2) This substance was slightly irritating to the skin of rabbits, producing minimal transient reddening and edema with slight flaking of the skin after 72 hours (ACGIH (7th, 2019)). (3) Moderate irritation was observed in skin irritation tests by 24-hour occlusive or 4-hour semi-occlusive application to rabbits (ECETOC TR64 (1995)). (4) This substance is slightly irritating to the skin (PATTY (6th, 2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 2B. [Evidence Data] (1) In an eye irritation test with rabbits, no severe irritation was shown and the effects were fully reversible within 7 days (ECETOC TR64 (1995), PATTY (6th, 2012)). (2) Results of eye irritation tests with rabbits ranged from non-irritating to moderately irritating (ACGIH (7th, 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) A skin sensitization test with guinea pigs (maximization method) on the acetate of this substance (CAS RN 54839-24-6) was negative, suggesting that the parent compound, this substance, would also be unlikely to possess skin sensitizing potential (ECETOC TR64 (1995), ACGIH (7th, 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There are no in vivo data. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) As for in vitro, there were reports of it being negative in a bacterial reverse mutation test and a chromosomal aberration test with human lymphocytes (ECETOC TR95 (2005)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1), as for developmental toxicity, no effects on embryos/fetuses were observed even at doses where maternal toxicity was observed. However, since there were no data on parental sexual function and fertility, it was classified as "Classification not possible" due to lack of data. [Evidence Data] (1) In tests in which female rats and rabbits were exposed by inhalation to the vapor of this substance during gestation, reduced body weight gain and decreased food consumption were observed in maternal animals, but no effects on fetal development were observed (ECETOC TR95 (2005), PATTY (6th, 2012), ACGIH (7th, 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (narcotic effects, respiratory tract irritation) |
Warning |
H336 H335 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 3 (narcotic effects, respiratory tract irritation). [Evidence Data] (1) In a 4-hour single inhalation exposure test with rats, at 10,000 ppm (42.5 mg/L, exceeding the range of Category 2), irritation of the eyes and nose and central nervous system depression were observed, but no mortality was reported (ACGIH (7th, 2019), PATTY (6th, 2012), ECETOC TR95 (2005)). (2) In another 4-hour single inhalation exposure test with rats, transient lachrymation, salivation, and central nervous system depression were observed at 2,213 ppm (9.59 mg/L, equivalent to Category 1), but no mortality was observed (ACGIH (7th, 2019), PATTY (6th, 2012), ECETOC TR95 (2005)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1), it is considered to correspond to "Not classified" in the inhalation route. The classification was not possible due to lack of data in the oral and dermal route. [Evidence Data] (1) In a 13-week inhalation exposure test with rats (6 hours/day, 5 days/week), increased urine volume was observed at or above 300 ppm (converted guidance value: 0.9 mg/L, within the range of Category 2), reversible eye and nose irritation, sedation and increased liver weights, and focal macrophage aggregation in the lungs were observed at 2,000 ppm (converted guidance value: 6.2 mg/L, exceeding Category 2) (ACGIH (7th, 2019), PATTY (6th, 2012), ECETOC TR95 (2005)). [Reference Data, etc.] (2) When rats were administered orally at 2 mL/kg 10 times, slightly reduced body weight gain and minor hematological changes in males, and increased liver weight in males and females were observed (ECETOC TR95 (2005)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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