Item | Information |
---|---|
CAS RN | 280-57-9 |
Chemical Name | Triethylenediamine |
Substance ID | m-nite-280-57-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Since its autoignition temperature is 350 degC (GESTIS (Access on Oct. 2010)), it is considered that the substance does not ignite at room temperature. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Among four data of the rat LD50 values (700, 1070, 1870 and 2260 mg/kg bw) (SIDS (2005)), three data corresponded to Category 4, and the other one corresponded to "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification). The substance was classified as Category 4, having the greatest number of data. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the report that the rabbit LD50 value was > 3200 mg/kg bw (SIDS (2005)) and no death was observed, the substance was classified as "Not classified". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Exposure at the saturated vapor pressure concentration (4.48 mL/L) /8hrs (converted value as that of 4-hour exposure: 8.96 mL/L) to rats caused no mortality (LC50: > 8.96 mL/L/4hrs) (SIDS (2005)). And in another study in rats, exposure at 20.2 mL/L/1h (converted value as that of 4-hour exposure: 5.05 mL/L) caused no mortality (LC50: > 5.05 mL/L/4hrs) (SIDS (2005)). Both test concentrations corresponded to "Not classified". The test concentration was higher than the saturated vapor pressure concentration (4.48 mL/L), the criterion values for dust/mist were adopted. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
The substance was classified as Category 2 based on the document that the primary dermal irritation index (PDII) was 4.05 in the rabbit Draize test (SIDS (2005)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
The substance was classified as Category 2 based on the document that PIS (primary irritation score) was 7.1/13 in the rabbit test (OECD TG 405, GLP-compliant) (SIDS (2005)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Not classified |
- |
- | - | The substance was classified as "Not classified" based on the document that non sensitization were reported in two guinea pig maximization tests (OECD TG 406, GLP-compliant) (SIDS(2005)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | The classification was concluded as "Not classified" based on the negative results in the mouse micronucleus test (in vivo mutagenicity test) (SIDS (2005)). As relevant information, as for in vitro study, negative results in the Ames test were reported (SIDS (2005)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In the combined repeated dose oral toxicity study with the reproduction/developmental toxicity study in rats (OECD TG 422, GLP-compliant), increased resorption, decreased live litter size, decreased postnatal pup survival and decreased pup body weights were observed in the high dose group that cause significant general toxicity in male and female parental animals (SIDS (2005)). Therefore, the substance was classified as Category 2. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
In the acute oral toxicity study in rats, administration at the dose levels of 1000 - 1500 mg/kg (equivalent to Category 2 of the guidance values) caused hypoactivity and ruffled coat, and the rats became semi-comatose to comatose within two hours, then some died and the remaining animals returned to normal within one to three hours. Gross necropsy revealed nothing remarkable (SIDS (2005)). Based on the information, the substance was classified as Category 2 (central nervous system). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (upper respiratory tract) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In the inhalation study in rats exposed for 6 hours/day, 5 days/week for 4 weeks (OECD TG 412, GLP-compliant), minimal to moderate chronic laryngitis was noted in the analytical dose levels of 0.06 and 0.41 mg/L, corresponding to Category 1 of the guidance values (converted values as that of 90-day study: 0.02 and 0.14 mg/L) (SIDS (2005)). Based on the information, the substance was classified as Category 1 (upper respiratory system). In addition, severe acute necrotizing laryngitis was observed in the dead females. In the combined repeated dose oral toxicity study with the reproduction/developmental toxicity screening test in rats for 28 days (OECD TG 422, 2 studies in compliance with GLP), the effects on the kidneys (inflammatory and/or proliferative lesions, acute pyelitis) or on the urinary bladder were found at the dose over the range of Category 2 (1000 mg/kg/day, converted dose level as that of 90-day study: 333 mg/kg/day) (SIDS (2005)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | Classified as "Not classified" from its 96h-LC50 = 1,730 mg/L for fish (Pimephales promelas) (AQUIRE, 2011). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Classified as "Not classified" since its acute toxicity is "Not Classified" and it is not non-water soluble (water solubility = 450 mg/L (PHYSPROP Database, 2011)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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