Item | Information |
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CAS RN | 4979-32-2 |
Chemical Name | N,N-Dicyclohexan-1-yl(1,3-benzothiazol-2-ylsulfanyl)amine |
Substance ID | m-nite-4979-32-2_v2 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | It is an organic compound not containing oxygen, fluorine or chlorine. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | The organic compound not including peroxy group in molecule. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Although in the Health, Labor and Welfare Ministry reports (Access on October 2008), LD0 values of the oral administration test (OECD TG 401, GLP) employing a rat were 1,821 mg/kg (male) and 1,077 mg/kg (female), the dose correlation was not found. However, LD50 values are estimated to be >= 1,821 mg/kg (male) and >= 1,077 mg/kg (female). Moreover, LD50 value >5,000 mg/kg and 6,420 mg/kg of the oral administration test employing a rat are shown in SIDS (2004). Furthermore, Patty (5th, 2001) describes that "LD50 value of acute toxicity (oral) is >5,000 mg/kg." . As mentioned above, LD50 value 6,420 mg/kg that was a definite value was adopted, and it was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | From a description of LD50 value of >2,000 mg/kg (SIDS (2004), Patty (5th, 2001), IUCLID (2000)) in the dermal administration test employing rabbits, it was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Although there is a description, "moderate skin irritation" (SIDS (2004))in the 24 hour Draize test using rabbits, classification is not possible, because it is the result under a severer condition than 4 hours. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | SIDS (2004) has described as "Not irritating" in the eye irritation test employing rabbits and as "slightly" in Draize test. As a conclusion, since SIDS (2004) has described as "slightly irritating to eyes in rabbits", it was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification is not possible since there is no data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Not classified |
- |
- | - | There is no data about humans. There is a description of "Not sensitizing" in the Maximization tests employing guinea pig (SIDS (2004), IUCLID (2000)), and it has been concluded that "there is no skin sensitizations" in SIDS (2004). Moreover, it was classified into "Not classified" since it has been concluded that "this substance is not a skin sensitizer" in Patty (5th, 2001) as well. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Since there is a description that the body cell in vivo mutagenicity test (chromosome aberration test (GLP) employing rats bone marrow cell) was "negative" (SIDS (2004)), it was carried "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Since no evaluation by major international evaluation agencies is made and there is a conclusion that "there is no research example with sufficient evidence" (SIDS (2004), Patty (5th, 2001), IUCLID (2000)), classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | It is reported in a Ministry of Health, Labor and Welfare Report (Access on October 2008), SIDS (2004) that in a combined repeated dose toxicity study and reproductive/developmental toxicity screening study in rats (OECD TG 422, GLP), "no changes in the rates of copulation and conception were observed, and it was judged that there were no effects." Moreover, for effects on fetuses and neonates and abnormalities in delivery and rearing at doses at which toxicities manifest themselves in mother animals, it is reported that "general toxicological effects are thought to be the greatest." However, in this study the data on teratogenicity in the offspring is insufficient. Since there is no other experimental data, classification is not possible. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
In the acute oral toxicity test employing a rat (OECD TG 401, GLP), "As symptoms, diminished locomotor activity, deep respiration, nerve tremor, spasm, etc., were observed. There is a description that these symptoms has recovered in the living animal on and after 7th day."(Health, Labor and Welfare Ministry reports (Access on October 2008)). Since this effect was seen within the range of the guidance value of Category 2, it was classified into Category 2 (central nervous system). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney, adrenal gland, thymus, central nervous system, respiratory system) |
Warning |
H373 | P260 P314 P501 |
It is written in the combination test of repeated dose toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that there was PAS positive hyaline droplet in proximal tubular epithelium of the kidney in males, and enlargement and fading of the kidney ,fatty degeneration of proximal tubular epithelium of the kidney, enlargement and fading of the adrenal gland, tabefaction, and decrease in locomotor activity in females, in addition, thymic atrophy in males and females"" (Ministry of Health, Labour and Welfare reports (Access on October 2008)). These effects were found within the scope of the guidance value of Category 2. Moreover, it is written in repeated inhalation exposure test in rats that "the irritation to mucosa is caused" (SIDS (2004)), and this effect was found within the scope of the guidance value of Category 2. Therefore, it was classified into Category 2 (kidney, adrenal gland, thymus, central nervous system, and respiratory system). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" from 72-hour ErC50 > 0.012 mg/L for algae (Raphidocelis subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013, SIAR, 2004), 48-hour EC50 > 0.031 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013), and 96-hour LC50 > 0.033 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013). | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 4 |
- |
H413 | P273 P501 |
If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1995)), 72-hour NOErC >= 0.0118 mg/L for algae (Raphidocelis subcapitata) (SIAR, 2004), and 21-day NOEC > 0.033 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained (fish), this substance is water-insoluble (water solubility = 0.0019 mg/L, SIAR, 2004), and 96-hour LC50 for fish (Oryzias latipes) is > 0.033 mg/L (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2001), EU CoRAP, 2013), but it is classified in Category 4 because it is not rapidly degradable and is bioaccumulative (BCF =3380-7310 (Fish bioconcentration test, 0.1-0.01 microg/L district (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 2001). By drawing a comparison between the above results, it was classified in Category 4. |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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