Item | Information |
---|---|
CAS RN | 50-32-8 |
Chemical Name | Benzo[a]pyrene |
Substance ID | m-nite-50-32-8_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | There is information that it is combustible (ICSC (J) (2005)), but there are no data in the prescribed test. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | An LD50 value for mice is reported to be > 1,600 mg/kg (EHC 202 (1998)), but the category cannot be determined. Therefore, the classification is not possible. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. Besides, it is described that it can cause a rash and burning sensations in the skin (HSDB (2010)), but no detailed data are mentioned. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. Besides, it is described that eye contact can cause irritations and burns (HSDB (2010)), but no detailed data are mentioned. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Data are lacking. Besides, positive reactions were reported in skin sensitization tests in guinea pigs and mice (adjuvant and patch test and mouse ear swelling test, respectively) (EHC 202 (1998)). However, these were not used for classification because each used the test method that was not approved by OECD, and a positive rate is unknown. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Category 1B |
Danger |
H340 | P308+P313 P201 P202 P280 P405 P501 |
It was classified in Category 1B based on a positive result in a dominant lethal test with mice (in vivo heritable germ cell mutagenicity test) (EHC 202 (1998)). Besides, it is reported that a mutual translocation test with mice (in vivo heritable germ cell mutagenicity test) was negative (EHC 202 (1998)), but as in vivo somatic cell mutagenicity tests, multiple chromosomal aberration tests with mouse bone marrow were all positive, a mouse spot test was positive, and a micronucleus test was also positive (EHC 202 (1998), NTP DB (Access on Aug. 2010)). Furthermore, as for in vivo somatic cell genotoxicity tests, a sister chromatid exchange test with mammal bone marrow cells and a DNA binding test and a DNA adduct formation test with mammal somatic cells gave all positive results (EHC 202 (1998), NTP DB (Access on Aug. 2010)). On the other hand, as for in vitro tests, mostly positive results were reported in Ames tests, and gene mutation tests and chromosomal aberration tests with cultured mammal cells (EHC 202 (1998), NTP DB (Access on Aug. 2010)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Category 1A |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
In a test by oral administration to mice on gestational days 7-16 (doses: 0, 10, 40, 160 mg/kg), significant decreases in gestation index and delivery index were observed in the 160 mg/kg/day group, and as a result of breeding by mating F1 males and females obtained in each group with untreated males and females, the pairs at or above 10 mg/kg/day showed significant decreases in gestation index, F1 females were infertile at or above 40 mg/kg/day, and F1 males were infertile at 160 mg/kg/day. The gonad was markedly small, testis weight was lower, the seminiferous tubules atrophied in F1 at or above 10 mg/kg/day, and the 40 mg/kg/day group had no semen. Also, in F1 females, ovaries were missing or rudimentary in most of them, and the 40 mg/kg/day group had no signs of follicle formation (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)). Stillbirths are reported after oral administration to rats during pregnancy (PATTY (5th, 2001)). From the above knowledge, although there were no descriptions of general toxicity in parent animals, adverse reproductive effects were observed, and the substance was classified in Repr. Cat.2; R60-R61 in EU classification. Therefore, it was classified in Category 1B. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (hematopoietic system) |
Warning |
H373 | P260 P314 P501 |
In a 90-day gavage administration test with male rats, significant decreases in erythrocyte counts, hemoglobin level, hematocrit value, and B cell percentage in the spleen were seen at or above 10 mg/kg/day, and at 90 mg/kg/day, in addition to decreased lymph node weight, significant decreases in leukocyte counts, bone marrow cells, natural killer cells in the spleen were observed. Decreases in erythrocyte counts, hemoglobin level, and hematocrit value were also seen at or above 50 mg/kg/day in a 90-day diet administration test with rats (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)). On the other hand, in a test in which two strains of mice having genetically different metabolizing enzyme activities (responsive and nonresponsive) were given 3-week oral administration of 120 mg/kg/day (converted guidance value: 28 mg/kg/day), no myelotoxicity was observed in responsive mice, but myelotoxicity (aplastic anemia, pancytopenia) occurred in nonresponsive mice, and all the animals died within three weeks, which was reported to be adverse hematopoietic effects (ATSDR (1995)). Because the doses of the above findings corresponded to the guidance value range for Category 2, it was classified in Category 2 (hematopoietic system). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
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