Item | Information |
---|---|
CAS RN | 624-83-9 |
Chemical Name | Methyl isocyanate |
Substance ID | m-nite-624-83-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Based on a flash point of -7 deg C (closed cup), and a boiling point of 39.5 deg C (HSDB (Access on July 2015)), it was classified in Category 2. Besides, it is classified in Division 6.1, Subsidiary Risk 3, PG I (UN 2480) in UNRTDG. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (cyanides) present in the molecule, but because it is classified in Division 6.1, Subsidiary Risk 3, PG I (UN 2480) in UNRTDG, it does not correspond to hazard class of the highest precedence, self-reactive substances and mixtures. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 534 deg C (HSDB (Access on July 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to liquid with lower boiling point are not available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
There are two reports of LD50 values for rats of 27-180 mg/kg (PATTY (6th, 2012)), 71 mg/kg (ACGIH (7th, 2001)). One corresponds to Category 3, and no category can be specified for the other one, therefore, it was classified in Category 3. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
There are two reports of LD50 values of 0.12-0.41 mL/kg (115-394 mg/kg) (PATTY (6th, 2012)) and 0.22 mL/kg (211 mg/kg) (ACGIH (7th, 2001)) for rabbits. Since one of them corresponds to Category 3, and for the other one, a category cannot be specified, it was classified in Category 3. Since the unit of LD50, which was used as the evidence in the previous classification, was not mg/kg but mL/kg, this was corrected, and the category was revised. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on a reported LC50 value (6 hours) of 6.1 ppm (converted 4-hour equivalent value: 7.5 ppm) (PATTY (6th, 2012), ACGIH (7th, 2001)) for rats, it was classified in Category 1. Besides, the LC50 value is lower than the saturated vapor pressure concentration (457,895 ppm), therefore, a reference value in the unit of ppm was applied as vapour without mist. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
There is a description that as a result of a 30-minute application of this substance to an auricle in a rabbit, erythema, edema, and necrosis were observed (HSDB (Access on August 2015)). In addition, there is a description that this substance is irritating to the skin in humans (PATTY (6th, 2012), HSDB (Access on August 2015)). From the above, it was classified in Category 2. Besides, this substance was classified in "Skin. Irrit. 2 H315" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
There are descriptions that this substance causes irreversible damage to human eyes (ACGIH (7th, 2001), HSDB (Access on August 2015)), and that it is severely irritating to the eyes (HSDB (Access on August 2015)). In addition, there is a report that as a result of exposure to this substance (1.75-5 ppm) in volunteers, irritation of the eyes was observed (PATTY (6th, 2012)). From the above description of irreversible damage, it was classified in Category 1. Besides, this substance was classified in "Eye Dam. 1 H318" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Category 1 |
Danger |
H334 | P304+P340 P342+P311 P261 P284 P501 |
Because there are multiple descriptions that an exposure to this substance causes asthma (HSDB (Access on August 2015)), it was classified in Category 1. Besides, this substance was classified in "Resp. Sens. 1 H334" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
There is a report that in an intracutaneous sensitization test with guinea pigs, immunological response was observed in all the test animals (16) (ACGIH (2001)), and there is a description that the skin sensitization was also caused in humans (HSDB (Access on August 2015)), therefore, it was classified in Category 1. Besides, this substance was classified in "Skin sens. 1 H317" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
As for in vivo, in the human epidemiological case, there is a report that the incidence of chromosomal aberrations in peripheral blood lymphocytes of two persons exposed to the gas of this substance was high (HSDB 2005). In micronucleus tests of peripheral blood erythrocytes of male and female mice exposed by inhalation, negative results (NTP DB (Access on August 2015)) and a weak but significant increase of micronuclei only at high doses (NTP DB (Access on August 2015)) were observed. As for in vitro, it was negative in a bacterial reverse mutation test, and positive in a mouse lymphoma test, a chromosomal aberrations test, and a sister chromatid exchange test with mammalian cultured cells (ACGIH (7th, 2001), NTP DB (Access on August 2015), PATTY (6th, 2012)). From the above, because there are positive results of in vivo somatic cell mutagenicity, it was classified in Category 2. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | In 2-year carcinogenicity tests on this substance by the inhalation route in rats or mice, a slight increase in the incidence of pheochromocytoma in the adrenal medulla and adenomas of pancreatic acinar cells only in male rats were observed, and no increase in the incidence of tumors in female rats or male and female mice was seen (HSDB (Access on August 2015)). Based on the fact that there is no available information on humans, and the results in experimental animals described above, US EPA classified it in Group D (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015)), but there is no classification result by other organizations. From the above, it was classified as "Classification not possible" for this hazard class. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
As a result of an investigation after interviewing pregnant women who had been neighborhood inhabitants to the factory in India and were possibly exposed to this substance in an accident at the factory, increases in the number of stillbirths, spontaneous abortions, and increased neonatal mortality after birth were reported (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015), HSDB (Access on August 2015)). Also for experimental animals, there is a description that in tests in which pregnant mice were given single inhalation exposure (day 8 of pregnancy) or 4-day inhalation exposure (days 14-17 of pregnancy), fetal toxicity such as low value of body weight or a slight increase in mortality in fetuses was observed with or without maternal toxicity (EPA Technology and Transfer Network Air Toxic Website (Access on August 2015), HSDB (Access on August 2015)). From the above, the case of epidemiological investigation is only the one from the accident, but the result is considered to be supported by animal tests to some extent, therefore, it was classified in Category 1B for this hazard class. Besides, this substance was classified in Repr. 2 in EU CLP classification (ECHA CL Inventory (Access on September 2015)). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
It is reported that inhalation exposure to this substance caused respiratory tract irritation, chest pain, coughing, labored breathing, vomiting, dyspnea and pulmonary edema, and oral exposure caused abdominal pain in humans (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on August 2015)). As for experimental animals, there are reports that inhalation exposure at 6.1 ppm (0.014 mg/L) (a dose corresponding to Category 1) caused lacrimation, hypoactivity, dyspnea, and oral respiration in rats, and the symptoms were mitigated within 2 weeks after exposure (ACGIH (7th, 2001), PATTY (6th, 2012)). From the above, because this substance causes respiratory tract irritation and effects on the respiratory organs, it was classified in Category 1 (respiratory organs). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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