Item | Information |
---|---|
CAS RN | 760-23-6 |
Chemical Name | 3,4-Dichloro-1-butene |
Substance ID | m-nite-760-23-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Since its flash point reported 33 degC (closed-cup) (IUCLID (2000)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | Although there are chemical groups (an unsaturated bond) present in the molecule associated with self-reactive properties, classification is not possible due to lack of additional data. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | There is a description, "Flammability: 2 (This degree includes materials that must be moderately heated before ignition will occur)" (HSDB (2003)). It is considered that the substance is not pyrophoric at room temperature. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine which is chemically bonded only to carbon. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
The rat LD50 values of 943 mg/kg (male), 946 mg/kg (female) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council (1996)), 879 mg/kg (SIDS (2001)) and 577 - 1153 mg/kg (SIDS (2001)) were documented. These all data are corresponded to Category 4. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | The rabbit LD50 value of > 2000 mg/kg and no mortality was reported (SIDS (2001)). The substance was classified as "Not Classified". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
Based on the rat LC50 value of 2100 ppm/4hrs (SIDS (2001)), the substance was classified as Category 3. Since the LC50 value was lower than 90% of the saturated vapor pressure concentration (28816 ppm), the criterion values for gas were adopted for the classification. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | In the 4-hour rabbit test (OECD TG404, GLP-compliant), application of 0.5 ml of the undiluted test substance for three animals caused slightly irritating with erythema (grade 1 or 2) until 72 hours after removal of patch in all animals. And the mean scores of erythema or edema at 24, 48 and 72 hours after removal of the patch were less than 2.3 (SIDS (2001)). Based on the document, the substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | In the rabbit test (OECD TG 405, GLP-compliant), instillation of 0.1ml of the undiluted test substance to conjunctival sac for three animals caused corneal opacity (grade 1) and iritis (grade 1) in 1 animal at 1-48 hours after instillation, and conjunctival redness (grade 1) in all three animals at 1 hour after instillation. Therefore, this substance was judged to be slight irritant. The mean scores of corneal opacity and iritis after 24, 48 and 72 hours of instillation was both 0 in 2 of 3 animals and those of conjunctival redness and edema were both under 2 in all 3 animals (SIDS (2001)). Based on the document, the substance was classified as "Not classified". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | In the guinea pig test, the substance was reported as not sensitizing (SIDS (2001)). However, because the details containing test methods were unknown, the substance was classified as "Classification not possible". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
The classification was concluded as Category 2 based on the positive results in the chromosomal aberration test using bone marrow cells obtained from the rats that were exposed by inhalation (in vivo mutagenicity test in somatic cells) (SIDS (2001)). As relevant information, as for in vitro mutagenicity studies, positive results in the Ames test, the chromosome aberration test using CHL/IU cells ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (1996)) and the HGPRT gene mutation assay using CHO cells (SIDS (2001)) were reported. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats (OECD TG 422, GLP-compliant), no adverse effects were documented on sexual functions and fertility containing the copulation index, fertility index, gestation length, gestation index and state of lactation in maternal animals. No treatment-related effect on the number of offspring and live pups, sex ratio, live birth index, viability index and morphological findings were detected in any of the offspring ("Toxicity Testing Reports of Environmental Chemicals"(Chemicals Investigation Promoting Council) (1996)). However, since the inspection for the fetal developmental at the end stage of gestation period was not performed, data were insufficient. Therefore, the substance was classified as "Classification not possible". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 1 (liver), Category 3 (narcotic effects) |
Danger Warning |
H370 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
In the single inhalation study in rats exposed to vaporized test substance to 3000 ppm/4hrs (15.3 mg/L/4hrs), dead animals the day of exposure showed centrilobular reduction of hepatocellular glycogen and fatty change. Even in the rats exposed to 1000 ppm/4hrs (5.11 mg/L/4hrs), equivalent to Category 1 of the guidance values, progress of liver lesions that led to centrilobular necrosis were observed after one day of exposure ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (1996)). Based on these findings, the substance was classified as Category 1(liver). Moreover, in the acute oral toxicity study in rats (LD50 value: 943-946 mg/kg), clinical signs observed after administration included decreased locomotor activity, deep respiration, ptosis, salivation, muscular relaxation, prone position, piloerection, etc. (SIDS (2001)). In another acute oral toxicity study in rats (LD50 value: 577-1153 mg/kg), the signs of weakness and narcotic symptoms were reported (SIDS (2001)). Further, clinical signs containing indifference to auditory and tactile stimuli in the acute dermal study (LD50 value: > 2000 mg/kg), as well as incoordination and refractory in the acute (vapor) inhalation study (LC50 value: 2100 ppm/4hrs (10.7 mg/L/4hrs)) were documented (SIDS (2001)). Based on the information, the substance was classified as Category 3 (narcotic effects). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver) |
Danger |
H372 | P260 P264 P270 P314 P501 |
In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity screening test in rats ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (1996)), increase in the liver weight and hypertrophy of hepatocytes were observed at 50 mg/kg/day (converted dose level as that of 90-day study: approx. 23 mg/kg/day). In the 6-month oral toxicity study in rats, degenerative changes in the liver were also reported (SIDS (2001)). Furthermore, it was described that exposure of the vapor of the substance to rats for 2 weeks at 1.037 mg/L/6hrs (converted value as that of 90-day study: 0.161 mg/L/6hrs) revealed increased relative liver weight and morphological changes in liver, and essential toxicity was hepatocellular hypertrophy (SIDS (2001)). Based on the findings described above, since the effect concentration in inhalation study was equivalent to Category 1 within the guidance values, the substance was classified as Category 1 (liver). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
Classified into Category 2 from its 48h-EC50 = 10 mg/L for crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1996). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (28d-BOD degradation rate = 1 - 28% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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