Chemical Management

Update history of Hazard Evaluation Support System Integrated Platform (HESS)

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August 2017

[HESS]
  • 1. Repeated dose Inhalation study data were added to the new sub-database(HESS RDT DB(Inhalation)).
    • * HPV
    • * New chemical substance data under CSCL
  • 2.New toxicological categories developed mostly in collaboration with KAO corporation (2 categories).

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February 2017

[HESS]
  • 1.Repeated dose toxicity study data were added to the database.
    • New chemical substance data under CSCL (38 chemicals, 38 studies total)
  • 2.New toxicological alert developed mostly in collaboration with KAO corporation (75 alerts).

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October 2016

[HESS]
  • 1.Repeated dose toxicity study data of Japanese CSCL were added to the database.(46 chemicals, 46 studies total)
[HESS DB]
  • 1.Repeated dose toxicity study data of Japanese CSCL were added to the database.(46 chemicals, 46 studies total)
  • 2.Toxicity mechanism information (3 chemicals, 3 references) were added.

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January 2016

[HESS]
  • 1.Repeated dose toxicity study data were added to the database.
    • * MHLW RDT data (24 chemicals, 24 studies total)
[HESS DB]
  • 1.Repeated dose toxicity study data were added to the database.
    • * MHLW RDT data (24 chemicals, 24 studies total)
  • 2.ADME information were added (247 chemicals, 380 references).
  • 3.Toxicity mechanism information (11 chemicals, 25 references) and summary of toxicity mechanism (2 chemicals) were added.

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July 2015

[HESS]
  • 1.The following repeated dose toxicity RDT test data were added.
    • * Tox-Omics RDT data (31 chemicals, 32 studies in total)
    • * TGP (Toxicogenomics) RDT data (124 chemicals, 124 studies in total)
    • * OECD HPV RDT data (130 chemicals, 150 studies total)
  • 2.Metabolic maps were added (150 chemicals, 159 maps in total)
  • 3.Nine categories of HPV chemicals were added.
[HESS DB]
  • 1.Tox-Omics repeated dose toxicity data (31 chemicals, 32 studies total) were added.

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January 2015

[HESS]
  • 1.Repeated dose toxicity study data of Japanese CSCL, NTP and OECD HPV chemicals (64 chemicals, 77 studies total) were added to the database.
  • 2.Profiler: Repeated dose (HESS): OECD HPV long chain alcohol category were added. Seven categories were updated in terms of data set chemicals.
[HESS DB]
  • 1.Dose response data of repeated dose toxicity study of Japanese CSCL and NTP chemicals (31 chemicals, 32 studies total) were added to the database.
  • 2.Reference information on toxicity mechanism (14 chemicals, 22 references) and 1 AOP were added to the database.

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July 2014

[HESS/HESS DB]
The following data were added to the databases:
  • 1.Repeated dose toxicity studies of 14 chemicals recently released under Japanese CSCL.
  • 2.Repeated dose toxicity studies of 50 drugs published in journals prior to registration in Japan.

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March 2014

[HESS/HESS DB]
  • 1.Repeated dose toxicity test data for existing chemicals under Japanese Chemical Substances Control Law (63 chemicals).
[HESS]
New features of HESS
  • 1.Function of profiling metabolites was equipped.
  • 2.Undo function was equipped.
Updated data
  • 1.Repeated dose toxicity test data kindly provided from COSMOS project (852 chemicals).
  • 2.Repeated dose toxicity test data kindly provided from ToxCast project (493 chemicals).
  • 3.New toxicological categories developed mostly in collaboration with KAO corporation (28 categories).
[HESS DB]
New features of HESS DB
  • 1.Compatible with 64 bit Windows 7/8.
  • 2.Improvement of data input by equipped "copy" & "paste" function.
Updated data
  • 1.Reference information on toxicity mechanism (32 chemicals, 60 refs, 8 AOP summaries)

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July 2013

[HESS/HESS DB]
Updated data
  • 1.Repeated dose toxicity test data for 16 existing chemicals under Japanese Chemical Substances Control Law (Chem No. 340, 524-538).
[HESS]
  • 1.Profiler: Repeated dose (HESS): Descriptions of some categories were updated.
  • 2.Profiler: Custom: A bug related to similarity boundaries setting was fixed.
  • 3.RDT Data: HESS repeated dose toxicity: A part of the endpoint tree was modified.
  • 4.RDT Data: HESS repeated dose toxicity: Some data were corrected.
[HESS DB]
  • 1.ADME information: Results of in silico P450 metabolism prediction were added to the database for 51 chemicals.
  • 2.Toxicity mechanism information: Nineteen references for 8 chemicals and 6 toxicity mechanism summary reports were added to the database.
  • 3.Link to original: The following links were updated.
    • * Toxicity data on the "Study_View" screen to the original toxicity test report
    • * Reference information on "ADME_View" screen to PubMed
    • * Reference information on "Mechanism_View" screen to PubMed

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January 2013

[HESS/HESS DB]
Updated data
  • 1.Repeated dose toxicity test data for 14 existing chemicals under Japanese Chemical Substances Control Law (Chem No. 354, 374, 512-523).
[HESS]
  • 1.Input: Added Study No. to input methods.
  • 2.Input: Added CAS querying when adding a post target.
  • 3.Input: Changed the way stereo is handled during input in order to match database chemicals.
  • 4.Profiler: Updated dendroid profiler visualization.
  • 5.Profiler: Updated some of the profilers.
  • 6.Profiler: Updated HESS profiler: updated training set chemicals in some of the categories.
  • 7.Profiler: Updated HESS profiler: changed is Counter profile - "Not categorized" instead of N/A.
  • 8.Categories: Fixed problem with filter.
  • 9.Reports: Updated.
[HESS DB]
  • 1.ADME information: Results of in silico P450 metabolism prediction were added to the database for 60 chemicals.
  • 2.Toxicity mechanism information: Information on 33 references for 12 chemicals were added to the database.

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July 2012

[HESS/HESS DB]
Updated data
  • 1.Repeated dose toxicity test data for 2 existing chemicals under Japanese Chemical Substances Control Law (Chem No. 510, 511).
[HESS]
  • 1.Profiling: Corrected a wrong table in the description of azobenzenes (Hemolytic anemia with methemoglobinemia) category in repeated dose (HESS) profiler.
  • 2.BUGFIX: Fixed a bug where RDT data for a post target chemical could not be gathered.
  • 3.BUGFIX: Fixed a bug where a name of saved filter could not be displayed.
[HESS DB]
  • 1.ADME information: Results of in silico P450 metabolism prediction were added to the database for about 50 chemicals.

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