GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Acrylic acid
CAS：79-10-7
Result：
| ID: | 2 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The flash point is 54degC (c.c.) (ICSC, 1999), which is classified into Category 3, those containing stabilizers are classified into Class 3 and Class 8 (UN#2218) (UN Recommendations on the Transport of Dangerous Goods) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though containing unsaturated bonds. Those containing stabilizers are classified into Class 3 and Class 8 (UN#2218) (UN Recommendations on the Transport of Dangerous Goods) |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 360degC (ICSC, 1999) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. Those containing stabilizers are classified into Class 3 and Class 8 (UN#2218) (UN Recommendations on the Transport of Dangerous Goods) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the LD50 value of 900 mg/kg calculated from the testing data of rat LD50 (oral route) of 193mg/kg (EHC 191(1997)), 360mg/kg (ACGIH (7th, 2001)), 1,250mg/kg (ACGIH (7th, 2001)), 1,350mg/kg (EHC 191(1997)), 2,500mg/kg (EHC 191(1997)), 2,520mg/kg (EHC 191(1997)7), and 2,590mg/kg (ACGIH (7th, 2001)). |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the LD50 value of 430mg/kg calculated from the testing data of rabbit LD50 (dermal route) of 295mg/kg, 640mg/kg, 750mg/kg and 950mg/kg (EHC 191 (1997)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |
|
Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the LC50 value (4 hours) of 3.6 with >5.100 mg/L (EHC 191 (1997)), calculated from testing data of rat (inhalation of vapor), with the smaller fixed value adopted. An LC50 value (4 hours) of 3.6 mg/L is converted into 1,200 ppm, using a conversion factor of 1 mg/L = 339 ppm. Based on the rat LC50 value (4 hours) was lower than 90% of the saturated vapor concentration (5,220 ppm) under a saturated vapor pressure of 529 Pa (25degC), Acrylic acid, under the test conditions, was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 4 |
|
Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the LC50 value (4 hours) calculated from the testing data of rat LC50 (inhalation of mist) of 11.1 mg/L (1 hour) and 7.5 mg/L (2 hours) (EHC 191 (1997)). Of LC50 values of 2.8 and 3.8 mg/L (4 hours) calculated, the lower value was adopted for classification purposes. |
| 2 | Skin corrosion/irritation | Category 1A |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in the report on rabbit skin irritation tests (EHC 191 (1997) and EU-RAR No.28 (2002)): 1-3-minitue application of the undiluted solution to the skin suggests corrosion. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description in the report on eye irritation tests (EHC 191 (1997) and EU-RAR No.28 (2002)): cicatrices in the eyelids and corneal opacity are still evident after 20 days of the application, both of which are considered irreversible effects. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Not classified | - | - | - | - | Based on the description in EHC 191 (1997) and EU-RAR No.28 (2002) - acrylic acid may or may not cause skin sensitization in guinea pigs. Impurities and polymerization inhibitors contained in acrylic acid cause skin sensitization, while purified acrylic acid does not, according to some reports. There is another report on industrial products containing acrylic acid that they have caused skin sensitization in more than 450 workers since 1989. Acrylic acid per se does not seem to cause skin sensitization. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the negative data on multi-generation mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo (chromosomae aberration tests) and the absence of data on germ cell mutagenicity tests in vivo, described in EU-RAR No.28 (2002). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category A4 by ACGIH (2001) and Group 3 by IARC (1999). This classification is in consistent with the evaluation of EU (2002): Acrylic acid is not suspected to be a carcinogenic agent (Based on these data, carcinogenic effects are not anticipated to occur.) |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Based on the report that no reproductive or developmental toxicity was observed at dosing levels not toxic to parent animals, described in EU-RAR No.28 (2002). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system), Category 2 (liver) |
|
Danger Warning |
H370: Causes damage to organs (respiratory system) H371: May cause damage to organs (liver) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. |
Based on the animal studies including "degeneration and necrosis of liver tissue (oral route); severe irritation of respiratory organs, pulmonary inflammation (inhalation route); pulmonary edema (dermal route)" (EU-RAR No.28 (2002)). The effects on the liver and on the respiratory organs were observed at dosing levels within the guidance value ranges for Category 2 and Category 1, respectively. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "inflammation of the upper respiratory tract" (CERI Hazard Data 96-27 (1997)), "degeneration of the olfactory epithelia" (MOE Risk Assessment Vol. 3 (2004)). The effects were observed at dosing levels within the guidance value ranges for Category 1. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 72 hours ErC50=0.13mg/L of the algae (Scenedesmus) (EHC191 (1997) and others.). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since there was rapidly degrading (the decomposition by BOD: 67.8% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.35 (PHYSPROP Database, 2005)), it was claasified into Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |