GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Adiponitrile
CAS：111-69-3
Result：
| ID: | 5 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Not classified | - | - | - | - | The flash point is 159degC (c.c.) (ICSC, 1999) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 550degC (ICSC, 1999) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | Classified into Division 6.1 (UN Recommendations on the Transport of Dangerous Goods, UN#2205) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 138mg/kg representing the lower of the two testing data, 138mg/kg (SIDS (1998)) and 300mg/kg (SIDS (1998)). |
| 1 | Acute toxicity （Dermal） | Category 5 | - | Warning | H313: May be harmful in contact with skin | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on the testing data of rabbit LD50 (dermal route) of 2,000mg/kg or more (SIDS (1998)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 2 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the testing data of rat LC50 (inhalation of dust/mist) of 1.71mg/L (SIDS, 1998). |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on the testing data of rabbit skin irritation tests (CERI Hazard Data 2001-17, (2002) and ACGIH (7th, 2001)), suggesting that the substance "has no irritation" and "no irritation". |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the description in the report on the rabbit skin irritation tests, "irritating" (SIDS (1998)), "slight irritation" (HSDB (2001)), "slightly irritating" (IUCLID (2000)): "Mild" |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Insufficient data available - very few test results have been reported with their details unknown, and no epidemiological data are available, though the results of guinea pig skin sensitization tests are all negative (CERI Hazard Data 2001-17 (2002), ACGIH (7th, 2001) and IUCLID (2000)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo and negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in CERI Hazard Data 2001-17 (2002) and SIDS (1998). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category D (not classifiable as to human carcinogenicity) by EPA (1991). |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Based on the description in CERI Hazard Data 2001-17 (2002) and ACGIH (7th, 2001), the results of rat reproductive toxicity and teratogenicity tests suggest no adverse effects on reproduction and development. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
|
Danger | H370: Causes damage to organs (nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence including "tightness of the chest, headache, debility (being barely able to stand), cyanosis, tachycardia, tachypnea, hypotension, pupillary dilatation, intermittent tonic contraction of limb/facial muscles" (MOE Risk Assessment Vol.3 (2004)), and the evidence from animal studies including "convulsions, lethargy, salvation, stridor" (CERI Hazard Data 2001-17 (2002)). The effects were observed at dosing levels within the guidance value ranges for Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (adrenal gland, blood system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (adrenal gland, blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "hemolytic anemia, a decrease in white blood cell count" (ACGIH (7th, 2001)), and the evidence from animal studies including "a decrease in mean corpuscular hemoglobin, hemoglobin concentrations, red blood cell count and hematocrit levels," and "adrenal degeneration" (MOE Risk Assessment Vol.3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | It was classified into Not classified from 24 hours EC50=445mg/L of the crustacea (Daphnia magna) (SIDS, 1998). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since it was not water-insolubility (the water-solubility =80000mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |