GHS Classification Result

Chemical Name:2-Aminoethanol
CAS:141-43-5

Result:
ID: 8
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
The flash point is 85degC (c.c.) (ICSC, 2004), which is classified into Category 4. Classified into Class 8 (UN#2491) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 410degC (ICSC, 2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available. Corrosivity to metals remains uncertain, though classified as "corrosive substances" (as the classification based on UN Recommendations on the Transport of Dangerous Goods includes "skin corrosivity") (UN#2491).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LD50 (oral route) of 3,320mg/kg (ACGIH (7th, 2001)).
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rabbit LD50 (dermal route) of 1,000mg/kg (ACGIH (7th, 2001)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 1A Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in the report on animal skin irritation tests (CERI Hazard Data 2001-41 (2002), ACGIH (7th, 2001)): "Corrosive" and "irritating, necrosis," the substance is thus considered "corrosive."
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2001-41 (2002), ACGIH (7th, 2001)): "Extremely irritating, causing corneal opacity and iris/conjunctival swelling," the substance is considered "extremely irritating to the eye and corrosive to the skin and eye."
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
Based on the description of the data on human health effects (CERI Hazard Data 2001-41 (2002)): "The results of inhalation provocative tests on aerosols (containing very low concentrations of 2-aminoethanol) are all positive in 14 subjects (cough, running nose, congested nose, asthmatic breathing). The substance is thus considered to cause "respiratory sensitization."
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the data on human health effects (CERI Hazard Data 2001-41 (2002)): "2-aminoethanol causes mild skin sensitization."
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on in vivo germ cell multi-generation mutagenicity tests and negative data on in vivo somatic cell mutagenicity tests(micronucleus tests), described in CERI Hazard Data 2001-41 (2002).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the results of rat teratogenicity studies (CERI Hazard Data 2001-41 (2002)): Pyelectasia is observed in the embryo at dose levels toxic to maternal animals.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, liver) Danger H370: Causes damage to organs (nervous system, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence including "headache, nausea, hyposthenia, dizziness, numbness in fingertips, pectoralgia" and "enlargement of the liver, an increase in serum ALT levels and alkaline phosphatase activity, chronic hepatitis (in six month's time)" (CERI Hazard Data 2001-41 (2002)), and the evidence from animal studies including "ataxia, convulsions," and "hepatocellular fatty degeneration" (CERI Hazard Data 2001-41 (2002)). The effects on nervous system and liver of experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, testis, gastrointestinal tract, liver, kidney, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, testis, gastrointestinal tract, liver, kidney, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "a decrease in locomotor activity, lethargy, skin irritation, irregular respiration, decease (83%) - with spermatogenesis inhibition and adverse effects on alimentary canal (degeneration of the small intestine wall, intestinal blockage due to dehydrated excrement) reported on the deceased subjects. Those in rodents include: hepatocellular fatty degeneration, an increase in lymphoid tissues in the pulmonary interstitium (CERI Hazard Data 2001-41 (2002)). Those in survived canines include: hepatic congestion, vacuolation and cloudy swelling of hepatocytes, an increase in brown pigments in Kupffer cells, a decrease in lymphocytes in the splenic white pulp, an increase in brown pigment phagocytic macrophage in the splenic red pulp, a decrease in red blood cells, an increase in hyaline granules in the renal tubular epithelium, cloudy swelling of the convoluted renal tubular epithelium, pulmonary congestion, small hemorrhagic focuses in the lung (CERI Hazard Data 2001-41 (2002)). Those in deceased canines include: bronchial pneumonia, a decrease in lymphocytes and red blood cells in the spleen (CERI Hazard Data 2001-41 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 72 hours ErC50=2.5mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 1996).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 83% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=-1.31 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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