GHS Classification Result

Chemical Name：O-Ethyl O-4-nitrophenyl phenylphosphonothioate; EPN
CAS：2104-64-5

Result：
ID: 11
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Cannot be classified due to lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups, with its oxygen budget calculated at -153). Classified into Division 6.1 (UN#2783 (Organophosphorus Pesticide, solid, toxic) (ICSC,1999)) (UN Recommendations on the Transport of Dangerous Goods).
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as "flammable" by ICSC (1999). Classified into Division 6.1 (UN#2783 (Organophosphorous Pesticide, solid, toxic) (ICSC,1999)) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not classified - - - - No data available, though the substance contains chemical groups associated with explosive properties that contain nitro groups. Classified into Division 6.1 (UN#2783 (Organophosphorous Pesticide, solid, toxic) (ICSC,1999)) (UN Recommendations on the Transport of Dangerous Goods).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#2783 (Organophosphorous Pesticide, solid, toxic) (ICSC,1999)) (UN Recommendations on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 36degC (ICSC,1999), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (insoluble, ICSC (1999)).
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#2783 (Organophosphorous Pesticide, solid, toxic) (ICSC,1999)) (UN Recommendations on the Transport of Dangerous Goods).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#2783 (Organophosphorous Pesticide, solid, toxic) (ICSC,1999)) (UN Recommendations on the Transport of Dangerous Goods).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 24mg/kg (Agricultural Chemical Registration Data (1987)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) value of 538mg/kg (Agricultural Chemical Registration Data (1987)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 (4 hours) value of 0.0265mg/L, calculated from the testing data of rat LC50 (inhalation) of 0.106mg/L (1 hour) (MOE Risk Assessment vol. 4 (2005)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (1988)): "The substance caused slight skin irritation which resolved within 72 hours."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description in the report on rabbit eye irritation tests (Agricultural Chemical Registration Data (1987)): The substance produced slight irritation of the conjunctiva, with effects fully resolving by day 7.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on no evidence of sensitization in guinea pig skin sensitization tests (Agricultural Chemical Registration Data (1987)).
5 Germ cell mutagenicity Not classified - - - - When tested in vitro, the substance was negative in Ames tests, chromosome aberration tests and UDS tests on Hela cells, and positive in chromosome aberration tests on human lymphocytes and gene mutation tests on mouse lymphoma cells. When tested in vivo, the substance was negative in mouse micronucleus tests (Agricultural Chemical Registration Data (1987)).
6 Carcinogenicity Not classified - - - - Available carcinogenicity studies in rats and mice provide no evidence of treatment-related increase in the incidence of tumor formation, reported in Agricultural Chemical Registration Data (1989). Also due to the fact that the substance is classified as Category A4 by ACGIH (2003).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of decreased viability of F1 and F2 on lactation day 4 at doses that caused parental toxicity in 2-generation reproductive toxicity studies in rats (Agricultural Chemical Registration Data (1988)).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the evidence of "decreased locomotor activity, impairment of sensory functions and lethargy probably due to cholinesterase inhibition" from single dose studies with rats (Agricultural Chemical Registration Data (1994)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence of "decreased locomotor activity, tremor, piloerection and abnormal gait probably due to cholinesterase inhibition" from repeated dose studies with rats (Agricultural Chemical Registration Data (1995)). These effects were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 4 days LC50=0.29microg/L of the crustacea (Pink Shrimp) (MOE Risk Assessment vol. 2, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since the acute toxicity was Category 1 and it had no rapidly degrading (the decomposition by BOD: 3% (Existing Chemicals Safety Check Data)), and it had the bio-accumulation (BCF=1590 (Existing Chemicals Safety Check Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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