NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Epichlorohydrin
CAS：106-89-8

Result：


ID:	14
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	The flash point is 31degC (c.c.) (ICSC, 2003), which is classified into Category 3. Classified into Class 3 and Division 6.1 (UN#2023) (UN Recommendations on the Transport of Dangerous Goods)
7	Flammable solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
8	Self-reactive substances and mixtures	Not classified	-	-	-	-	Classified into Class 3 and Division 6.1 (UN#2023) (UN Recommendations on the Transport of Dangerous Goods).
9	Pyrophoric liquids	Not classified	-	-	-	-	Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 395degC (ICSC, 2003)
10	Pyrophoric solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing oxygen and chlorine (but not fluorine), with the oxygen and chlorine bound to carbon and hydrogen, respectively (but not to other elements)
14	Oxidizing solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Not classified	-	-	-	-	Classified into Class 3 and Division 6.1 (UN#2023) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 90mg/kg representing the lower of the two testing data, 90mg/kg (MOE Risk Assessment vol. 1, 2002) and 260mg/kg (EHC 33 (1984)).
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the testing data of rabbit LD50 (dermal route) of 754mg/kg (EHC 33 (1984)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the LC50 value (4 hours) of 250ppm, calculated from the testing data of rat LC50 (inhalation of vapour) of 0.95mg/L (4 hours) (MOE Risk Assessment vol. 1 (2002)) and 2.4mg/L (4 hours) (EHC 33 (1984)), was lower than 90% of the saturated vapour concentration (16,000ppm) under a saturated vapour pressure of 1.6kPa (20degC) (ICSC (2003)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 1A-1C		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the testing data of rabbit skin irritation tests (CERI-NITE Hazard Assessment No.74 (2004)) and data on human health effects (CERI-NITE Hazard Assessment No.74 (2004), ACGIH (7th, 2001), MOE Risk Assessment Vol. 1 (2002)) suggesting the substance is "corrosive," although the substance should be placed in Category 1A from the viewpoint of safety.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	Based on the testing data of rabbit eye irritation tests (CERI-NITE Hazard Assessment No.74 (2004)) and data on human health effects (ACGIH (7th, 2001), MOE Risk Assessment Vol. 1 (2002), EHC 33 (1984)), the substance is considered "extremely irritating." Although no data are available on the corrosiveness, the results of rabbit eye irritation tests suggest that 80% epichlorohydrin causes "severe irritation (corneal damage)"; 100% epichlorohydrin may be corrosive.
4	Respiratory sensitization	Category 1		Danger	H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled	P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ...	Based on the description in MOE Risk Assessment Vol. 1 (2002): "The data on human health effects include chronic asthmatic bronchitis." The substance is thus considered to cause "respiratory sensitization."
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Classified into Category 1, based on the testing data of guinea pig skin sensitization tests (CERI-NITE Hazard Assessment No.74 (2004)) and data on human health effects (CERI-NITE Hazard Assessment No.74 (2004), ACGIH (7th, 2001), MOE Risk Assessment Vol. 1 (2002), EHC 33 (1984)). The substance is considered to cause "skin sensitization."
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on negative data on multi-generation mutagenicity tests in vivo, the absence of data on germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), and absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.74 (2004).
6	Carcinogenicity	Category 1B		Danger	H350: May cause cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Due to the fact that the substance is classified as Category R by NTP (2005) and Group 2A by IARC (1999).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the description in rat toxicity studies (CERI-NITE Hazard Assessment No.74 (2004)): Reproductive toxicity is observed (female infertility), while other toxicities are unknown.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system, liver, kidney)		Danger	H370: Causes damage to organs (respiratory system, liver, kidney)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the human evidence including "irritation to the eye and larynx (observed at 151 mg/m3, which continues for 48 hours)" (CERI-NITE Hazard Assessment No.74 (2004), "irritation to the larynx, enlargement of the liver associated with jaundice, hepatic fatty degeneration associated with hepatopathy (observed even after two years of exposure), chronic asthmatic bronchitis" (CERI Hazard Assessment 96-48 (1998)), and the evidence from animal studies including "necrosis and ulceration of the respiratory tract and olfactory epithelia, exfoliation and hyperplasia of the tract epithelium, exfoliation of bronchiole epithelium, renal failure, an increase in the relative weight of the kidneys, an increase in urinary specific gravity, polyuria associated with an increase in urinary protein/chloride concentrations; renal damage associated with vacuolation, hepatic fatty degeneration, focal necrosis of the gastrointestinal tract" (CERI-NITE Hazard Assessment No.74 (2004)). The effects on respiratory organs and kidneys of experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system, kidney, heart, central nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, heart, central nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "renal tubular dilation, renal tubular degeneration, turbinate respiratory epithelium inflammation, localized inflammation, hyperplasia, squamous metaplasia, changes in the respiratory epithelium" (CERI-NITE Hazard Assessment No.74 (2004)), "pulmonary emphysema, pulmonary edema, bronchial pneumonia, cloudy swelling of proximal convoluted renal tubules, hemorrhage and congestion in the cardiac interstitium, lesions in the hindbrain, Ammon's horn (the hippocampus) and cerebellum" (CERI Hazard Data 96-48 (1998)). The effects were observed at dosing levels within the guidance value ranges for Category 1.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 3 from 96 hours LC50=10600microg/L of the fish (Fathead Minnows) (MOE Risk Assessment vol. 1 (2002) and others.).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Since there was rapidly degrading (the decomposition by BOD: 67.9% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.45 (PHYSPROP Database, 2005)), it was claasified into Not classified.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）