GHS Classification Result

Chemical Name:Cadmium oxide
CAS:1306-19-0

Result:
ID: 15
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC,1999)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC,1999)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,1999)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water-insoluble ICSC (1999))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to the absence of data, though being inorganic compounds containing oxygen.
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 72mg/kg representing the lower of the two testing data, 72-296 mg/kg (CaPSAR, 1994) and 72 mg/kg (CERI Hazard Data 97-17, 1998).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the leathal dose of 0.011 mg/L calculated from the testing data of human leathal dose (4 hour exposure to cadmium oxide fume) of 0.01mg/L (ACGIH 7th, 2001), 0.012 mg/L (EHC 134, 1992) and 0.011 mg/L (EHC 134, 1992).
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data available
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the absence of data on heritable mutagenicity tests and germ cell mutagenicity and genotoxicity tests in vivo and positive data on somatic cell mutagenicity tests in vivo (human peripheral blood lymphocyte chromosome tests), described in NTP TOX39 (1995), NTP DB (Access on December 2005) and IARC 58 (1993).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category A2 (as cadmium and cadmium compounds) by ACGIH (2001).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of foetal weight reduction at dosing levels causing general toxicity in rat developmental toxicity tests, described in CERI Hazard Data 97-17 (1998), NTP TOX39 (1995) and IARC 58 (1993).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence including "pneumonia" (ACGIH (7th, 2001)), "breathing difficulties, cough, myalgia and fever, infiltrative shadows observed in chest X-ray" and "advanced pulmonary fibrosis found 9 years after exposure without improvement in pulmonary function" (ATSDR (1999)) and the evidence from animal studies including "interstitial pneumonia, hyperplasia of alveolar epithelial cells and fibroblasts" (CERI Hazard Data 97-17(1998)), "diffuse alveolitis associated with hemorrhage, edema and monocyte layers" and "breathing difficulties and discolored lungs" (ATSDR, 1999). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. [Note] The characteristic symptoms of acute toxicity of cadmium compounds are "chemical pneumonia and pulmonary edema through inhalation exposure and acute severe nausea, vomiting and abdominal pain through oral intake" (EHC 134, 1992).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, kidney, bone, heart, hematopoietic system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, bone, heart, hematopoietic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "glomerular filtration dysfunction" (ACGIH 7th, 2001), "decrease in forced vital capacity in high-dose groups" (ATSDR, 1999) and "direct effects on bone metabolism (EHC 134, 1992) and the evidence from animal studies including "injury of myocardial intercalated disc", "neutrophilia, lymphopenia and anemia" (CERI Hazard Data 97-17, 1998), "pulmonary emphysema" (ATSDR, 1999), "necrosis of pulmonary alveoli and surrounding tissues and cell infiltration" and "histopathological changes in lungs, pharynx and nasal cavity of the treated groups" (NTP TOX, 1995). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. [Note] The characteristic symptoms of chronic toxicity of cadmium compounds are "nephropathy including glomerular proteinuria and the resulting hypercalciuria, unbalanced ratio between calcium and phosphate, decrease in blood phosphate level, nephrolithiasis, osteoporosis and osteomalacia. (EHC 134, 1992).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 72 hours EC50=79microg/L (Cadmium Oxide Equivalent: 90microg/L) of the algae (Green Algae) (EU-RAR, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity was Category 1 and bio-accumulation was low (BCF=20 (Existing Chemical Safety Inspections Data)), since it was a metallic compound and the underwater action was unknown, it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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