GHS Classification Result

Chemical Name：Cresol
CAS：1319-77-3

Result：
ID: 17
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" (m-cresol) or "solid" (o- and p-cresol), according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" (m-cresol) or "solid" (o- and p-cresol), according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" (m-cresol) or "solid" (o- and p-cresol), according to GHS definition
6 Flammable liquids Category 4 (m-form), Not applicable (o-form, p-form) - Warning H227: Combustible liquid (m-form) P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flashing point is 86degC (ICSC 1999) for m-cresol (Category 4); classified into Category 6.1 and Class 8 (UN Recommendations on the Transport of Dangerous Goods, UN#2076 and 3455). Classified as "solid" (o- and p-cresol), according to GHS definition
7 Flammable solids Not applicable (m-form), Not classified (o-form, p-form) - - - - Classified as "liquid" (m-cresol), according to GHS criteria. Classified into Division 6.1 and Class 8 (UN Recommendations on the Transport of Dangerous Goods, UN#2076 and 3455) (o- and p-cresol).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified (m-form), Not applicable (o-form, p-form) - - - - Not pyrophoric when in contact with air at ordinary temperatures: the flashing point is 626degC for m-cresol (ICSC,1999). Classified as "solid"(o- and p-cresol), according to GHS definition
10 Pyrophoric solids Not applicable (m-form), Not classified (o-form, p-form) - - - - Classified as "liquid"(m-cresol), according to GHS definition. Not pyrophoric when in contact with air at ordinary temperatures: the flashing points are 599degC for o-cresol (ICSC, 2000) and 559degCfor p-cresol (ICSC, 2000).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available; the melting points are 30degC for o-cresol (ICSC, 2000), 11-12degC for m-cresol (ICSC, 1999) and 35degCfor p-cresol (ICSC, 2000) (test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) (m-cresol). Classified as "solid" (o- and p-cresol), according to GHS criteria.
14 Oxidizing solids Not applicable - - - - Classified as "liquid" (m-cresol), according to GHS criteria. Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) (o- and p-cresol).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available. Corrosivity to metals remains uncertain, though classified as "corrosive substances" (as the classification based on UN Recommendations on the Transport of Dangerous Goods includes "skin corrosivity") (UN#2076 and 3455).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the testing data of rat LD50 (oral route) of 1,454 mg/kg (IUCLID, 2000).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the testing data of rabbit LD50 (dermal route) of 2,000 mg/kg (EHC 168, 1995).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" (o- and p-cresol) or "liquid" (m-cresol) according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of "irreversible destruction of skin tissues" (EHC 168, 1995) from the rabbit skin irritation test, although the substance should be placed in Category 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the evidence of "corneal opacity and arterialization" from the rabbit eye irritation test (CERI Hazard Data 97-9-1, 1998).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the technical guideline (Appendix 1). CAS1319-77-3 does not define the isomeric composition (o, p or m) or the positions of the methyl and hydroxyl groups in cresol, and there is no data on the in vivo mutagenicity of isomeric mixtures. However, cresol (mixture) is considered to have no in vivo mutagenicity in general, based on the evidence from EHC 168 (1995) and NTP TOX9 (1992) that 60:40 m/p-cresol was negative for somatic cell mutagenicity in vivo (demonstrated in mouse micronucleus test using red blood cells), o-cresol was negative in mouse micronucleus test using red blood cells and in mouse dominant lethal test and m-cresol was negative in mouse bone marrow chromosome aberration test.
6 Carcinogenicity Not classified - - - - Due to the fact that each of the cresol isomers (o-, m- and p-cresol) is placed in Category C by EPA (1991), although cresol (CAS No. 1319-77-3) itself is not placed in any category for carcinogenicity.
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 1 (blood system, respiratory system, heart, liver, kidney, central nervous system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (blood system, respiratory system, heart, liver, kidney, central nervous system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "deep coma, severe methemoglobinemia, formation of Heinz bodies, intravascular hemolysis, clot formation, liver fatty degeneration, kidney fatty degeneration, tubulonecrosis" (CERI Hazard Data, 97-9, 1998) and "myocardial dysfunction, hemorrhagic pulmonary edema, necrosis of hepatic lobules, necrosis of kidneys, brain congestion, brain swelling (EHC 168, 1995) and evidence from animal studies including "clonic spasm, bloody urine, airway irritation, necrosis of the lung and liver" (DFGOT Vol. 14, 2000). The effects on experimental animals were observed at dosing levels within the guidance value range for Category 1.The basis of the classification includes data on cresol with unknown composition or containing other substances.
9 Specific target organ toxicity - Repeated exposure Category 1 (cardiovascular system, blood system, kidney, central nervous system), Category 2 (respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (cardiovascular system, blood system, kidney, central nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "circulatory disorder, minor decreases in red-cell, white-cell and platelet counts" (MOE Risk Assessment Vol. 2, 2003) and "headache, nausea, vomiting, hypertension, renal impairment, abnormal blood levels of calcium, significant tremor" (DFGOT Vol. 14, 2000) and the evidence from animal studies including "hyperplasia of nasal respiratory epithelium" (CERI Hazard Data 97-9-2, 1998 and 97-9-3, 1998). The effects on experimental animals were observed at dosing levels within the guidance value range for Category 2. The basis of the classification includes data on cresol with unknown composition or containing other substances and mixtures of m- and p-cresol.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=7mg/L of the crustacea (Amphipod) (CERI/NITE Hazard Assessment Report (preliminary version), 2006).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition (ortho, meta and para isomer): >60% (SIDS (1998, 2005)) and the bio-accumulation was low (log Kow=1.95 (PHYSPROP Database (2005))), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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