Chemical Name:p-Cresol
CAS:106-44-5
ID: | 20 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Not classified | - | - | - | - | Classified into Division 6.1 and Class 8 (UN Recommendations on the Transport of Dangerous Goods, UN#3455 Cresol (solid)) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 559degC (ICSC, 2000) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available - melting point: 35degC (ICSC, 2000), test temperature: 140degC |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. Corrosivity to metals remains uncertain, though classified as "corrosive substances" (as the classification based on UN Recommendations on the Transport of Dangerous Goods includes "skin corrosivity") (UN#3455 Cresol (solid)). |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the testing data of rat LD50 (oral route) of 207mg/kg (EHC 168 (1995)). | |
1 | Acute toxicity (Dermal) | Category 3 | Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the animal LD50 (dermal route) value of 300mg/kg representing the lower of the two testing data, 750mg/kg and 300 mg/kg (EHC 168 (1995)). | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | Insufficient data available |
2 | Skin corrosion/irritation | Category 1A-1C | Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of "irreversible destruction of skin tissues" (EHC 168 (1995)) from the rabbit skin irritation test, although the substance should be placed in Category 1A from the viewpoint of safety. | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description in the report on rabbit eye and skin irritation tests: "Severe irritation to the conjunctiva, cornea and iris is observed, which does not recover within 72 hours" (SIDS (2005)) and "Irreversible damage to the skin is observed" (EHC 168 (1995)). | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Not classified | - | - | - | - | Based on the description in the report on guinea pig skin sensitization tests (DFGOT Vol.14 (2000)) and data on human health effects (SIDS (2005)) - both negative. |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the negative resulrts in multi-generation mutagenicity (dominant lethal test), the absence of the data on germ cell mutagenicity tests in vivo and somatic cell mutagenicity tests in vivo, described in CERI Hazard Data 97-9 (iii) (1998), ATSDR (1992), SIDS (2005) and NTP DB (Access on October 2005). |
6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category C by EPA (1991). |
7 | Reproductive toxicity | Not classified | - | - | - | - | Based on the description in MOE Risk Assessment Vol. 1 (2002), CERI Hazard Data 97-9 (iii) (1998) and ATSDR (1992): The results of reproductive toxicity tests suggest no adverse effects on reproduction function and ability. It should be noted, however, some teratogenicity studies reported on minor skeletal defects in rat embryos. |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, kidney), Category 3 (respiratory tract irritation) |
Danger Warning |
H370: Causes damage to organs (central nervous system, kidney) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the evidence from animal studies including "a decrease in locomotor activity, tremor, lacrimation, lacrimation, dyspnea, cyanosis, hemorrhagic rhinitis, convulsions, physical collapse, irritation to the nasal cavity, nervous muscular excitement, hematuria" (SIDS (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (respiratory system, central nervous system) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, central nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "hyperplasia of nasal respiratory epithelium, squamous epitheliummetaplasia" (CERI Hazard Data 97-9 (iii) (1998)), "salivation, tremor, abdominal contamination from urine, a decrease in locomotor activity, tachypnea, labored breathing, clonic spasm, hyperreaction" (SIDS (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 48 hours LC50=1.4mg/L of the crustacea (Daphnia magna) (EHC168 (1995) and others.). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since there was rapidly degrading (40 days decomposition (the OECD testing guideline 301C): 80-95% (SIDS, 2005)), and bio-accumulation was low (log Kow=1.94(PHYSPROP Database, 2005)), it was classified into Not classified. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |