GHS Classification Result

Chemical Name：Chloromethane; Methyl chloride
CAS：74-87-3

Result：
ID: 25
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Classified as "gas" according to GHS definition
2 Flammable gases （including chemically unstable gases） Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place. 		Based on the description in ICSC (2000): the lower explosion limit is 8.1vol%. Classified into Division 2.1 (UN#1063) (UN Recommendations on the Transport of Dangerous Goods)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not classified - - - - Classified into Division 2.1 (UN#1063) (UN Recommendations on the Transport of Dangerous Goods)
5 Gases under pressure Liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. The boiling point is -24.2degC (ICSC 2000), and the critical temperature is 143.10degC (HSDB 2005) - i.e., liquefied gases. Classified into Division 2.1 (UN#1063) (UN Recommendations on the Transport of Dangerous Goods)
6 Flammable liquids Not applicable - - - - Classified as "gas" according to GHS definition
7 Flammable solids Not applicable - - - - Classified as "gas" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Classified as "gas" according to GHS definition
9 Pyrophoric liquids Not applicable - - - - Classified as "gas" according to GHS definition
10 Pyrophoric solids Not applicable - - - - Classified as "gas" according to GHS definition
11 Self-heating substances and mixtures Not applicable - - - - Classified as "gas" according to GHS definition
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Classified as "gas" according to GHS definition
13 Oxidizing liquids Not applicable - - - - Classified as "gas" according to GHS definition
14 Oxidizing solids Not applicable - - - - Classified as "gas" according to GHS definition
15 Organic peroxides Not applicable - - - - Classified as "gas" according to GHS definition
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Insufficient data available, though classified into Category 4 according to the rat LD50 (oral route) of 1,800mg/kg (IUCLID (2000)) (The details of the administration are unknown.)
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the testing data of rat LC50 (inhalation of gas) of 2,566ppm (SIDS (2004)), representing the lower of the two testing data, 2,566mg/kg (SIDS (2004)) and 2,700mg/kg (SIDS (2004)).
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected.
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected.
2 Skin corrosion/irritation Classification not possible - - - - No data available. Exposure to the liquefied gas may cause frostbite (ICSC (J) (2000)).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available. Exposure to the liquefied gas may cause frostbite (ICSC (J) (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive data on multi-generation mutagenicity tests (dominant lethal tests), described in SIDS (2004).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Group 3 by IARC (1999), Category A4 by ACGIH (2001) and Group D by EPA (2001).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on mouse teratogenicity tests (CERI-NITE Hazard Assessment No.40 (2004)): malformations are observed in offspring at dose levels not toxic to parent animals.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, cardiovascular system), Category 2 (liver, kidney), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system, cardiovascular system)
H371: May cause damage to organs (liver, kidney)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "dizziness caused by inhalation exposure, debility, blurred vision, ataxia, lethargy, insomnia, confusion, paresthesia, neurosis, ademonia, nausea," "severe headache caused by oral ingestion, intoxication, somnolency, ataxia, speech disorder" and "electrocardiographic abnormality, tachycardia, an increase in hear rate, a decrease in blood pressure" (CERI-NITE Hazard Assessment No.40 (2004)) and the evidence from animal studies including "toxicity to the liver and kidneys, cerebellar degeneration" (CICAD 28 (2000). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, kidney, central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "jaundice, anuria, albuminuria" (CERI-NITE Hazard Assessment No.40 (2004)), "adverse effects on the central nervous system such as difficulties in accommodation and diplopia" (ACGIH (7th, 2001)) and "adverse effects on the liver and kidneys" (ACGIH 7th (2001)).
10 Aspiration hazard Not applicable - - - - Not applicable

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It was classified into Not classified from 48 hours EC50=200mg/L of the crustacea (Daphnia magna) (SIDS (2004) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it was not water-insolubility (the water-solubility =5320mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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