GHS Classification Result

Chemical Name：Tetrachloromethane
CAS：56-23-5

Result：
ID: 29
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - Non-combustible (ICSC,2004)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC,2004)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#1846) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the LD50 value of 2,350mg/kg calculated from the testing data of rat LD50 (oral route) of 2,350mg/kg (MOE Risk Assessment Vol. 1, 2002), 2,821mg/kg and 10,054mg/kg (EHC 208, 1999).
1 Acute toxicity （Dermal） Not classified - - - - Based on the testing data of rat LD50 (dermal route) of 5,070mg/kg (CERI Hazard Data 97-1, 1998).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on the testing data of rat LC50 (4 hour inhalation of vapor) of 8,000ppm (MOE Risk Assessment Vol. 1, 2002) was lower than 90% of the saturated vapor concentration (151,000ppm) under a saturated vapour pressure of 15.3 kPa (25degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the evidence of "moderate irritation" in rabbit skin irritation tests (CERI-NITE Hazard Assessment No. 67, 2005).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the following description from the report on rabbit eye irritation tests (CERI-NITE Hazard Assessment No. 67, 2005): "irritation was observed but completely disappeared by 14 days after exposure".
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on heritable mutagenicity tests and germ cell mutagenicity tests in vivo and negative data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in CERI-NITE Hazard Assessment No. 67 (2005), ATSDR (2005).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category R by NTP (2005), Group 2B by IARC (1999), Category B2 by EPA (1991) and Category 2B by the Japan Society for Occupational Health.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of absorbed embryos and adverse effects on male genital organs at dosing levels toxic to parent animals, described in CERI-NITE Hazard Assessment No. 67 (2005), ATSDR (2005) and EHC 208 (1999).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, liver, kidney) Danger H370: Causes damage to organs (central nervous system, liver, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "vomiting, diarrhea, dizziness, headache, coma, loss of hepatic function, jaundice, hepatic enlargement, nephropathy and acute renal failure" (CERI-NITE Hazard Assessment No. 67, 2005) and the evidence from animal studies including "centrilobular necrosis of the liver" (EHC 208, 1999). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, blood, kidney, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, blood, kidney, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "significant increases in ALT and gamma-GTP, cirrhosis" (CERI-NITE Hazard Assessment No. 67, 2005) and the evidence from animal studies including "vacuolation of centrilobular hepatocytes, histological changes in the liver (fatty degeneration, hepatocyte degeneration, ceroid deposition, bile duct proliferation, increase in mitosis, polymorphism and small hyperplastic foci of hepatocytes), thrombosis and necrosis of the liver, increased hemosiderin deposition in the spleen, hematological changes, abnormal urinalysis, protein cast accumulation in the kidney, progressive glomerulonephritis, acidophilic changes in the nasal mucosal epithelium" (CERI-NITE Hazard Assessment No. 67, 2005). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72 hours ErC50=0.46mg/L of the algae (Green Algae) (MOE Eco-Toxicity Tests of Chemicals, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=11(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information