GHS Classification Result

Chemical Name:O-ethyl O-(4-methylthiophenyl) S-propyl dithiophosphate
CAS:35400-43-2

Result:
ID: 31
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Not classified because it "may burn but does not ignite readily (HSDB, 2005)"
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - It carried out the outside of Category by the statement of may burn but does not ignite readily (HSDB (2005)).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Since there is a data of water solubles, it carried out the outside of Category for not being water reactive.
13 Oxidizing liquids Classification not possible - - - - Classification not possible due to lack of data, though organic compounds containing oxygen chemically bonded to phosphorus (but not fluorine and chlorine).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
SPECIES: Rat ENDPOINT: LD50 VALUE: 100-300mg/kg REFERENCE SOURCE: ACGIH (2001) SPECIES: Rat ENDPOINT: LD50 VALUE: 107-304mg/kg (male), 65-275mg/kg (female) REFERENCE SOURCE: PATTY (5th, 2001)
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into Category 3 from the description of rabbit LD50: male 820m/kg, female 994mg/kg (PATTY (5th, 2001)) and 800 - 1000 mg/kg (ACGIH (2001)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - There is no data, and it cannot be classified. (generation of vapor can be disregarded in room temperatures.)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - There is no data and it cannot classify. (There is a data of mouse and hamster LC50 >0.49mg/L/4H (PATTY (5th, 2001)), and Category 3 and 4 can be assumed. )
2 Skin corrosion/irritation Not classified - - - - It was classified as out of Category from the statement of having no stimulativeness on the examination with rabbits (ACGIH (2001)).
3 Serious eye damage/eye irritation Not classified - - - - It was set as the outside of Category from the statement of having no stimulativeness (ACGIH (2001)) by the examination of the rabbit.
4 Respiratory sensitization Classification not possible - - - - Classified as uncategorizable because of no data.
4 Skin sensitization Not classified - - - - Classified as out of category because the guinea pig test using a pure product came negative. (A test using an end-use product can result positive.)
5 Germ cell mutagenicity Not classified - - - - Because of the reports indicating negative results in the dominant lethal test in mice (ACGIH (2001)), the mouse micronucleus test (PATTY (5th, 2001)) and in the in vitro test (the Ames test, sister chromatid exchange test) (ACGIH (2001), PATTY (5th, 2001)). So the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - - There is the description that carcinogenicity was not observed in mouse and dog test (PATTY (5th, 2001)). And it was set as the outside of Category from being classified into A4 according to ACGIH.
7 Reproductive toxicity Not classified - - - - The fetotoxity and teratogenicity were not observed but maternal toxicity (feed consumption and weight reduction) was observed (ACGIH(2001)) in the pregnant animals oral administration test of rat and rabbit, maternal toxicity, ferotoxity and teratogenicity was not observed in the pragnant animals oral administration test of rat (PATTY (5th, 2001)), and reproductive toxicity was not observed in three generation test of rat (inhalation exposure) (ACGIH(2001)). Based on the above, it was put on the outside of category.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Suppression of the central nervous system, such as headaches, dizziness, convulsions and respiratory failure are observed, and other effects on the nervous system, such as constriction of the pupils, arrhythmia and muscle spasms, are observed as acute toxicity symptoms in humans (EHC 63 (1986), ICSC (1993), HSDB (2005)). Moreover, there is the report of suppression of cholinesterase activity in sera, erythrocytes and the brain within the guidance values for Category 1 in the single-dose study (PATTY (5th, 2001)). So the substance was classified as Category 1 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since in the repeted oral or inhalation administration with rat, inhibition in cholinesterase activities was observed within the guidance value of Category 1(ACGIH (2001), PATTY (5th, 2001)), and as a human chronic toxicity symptoms, because of the description of headaches, weakness, failure of memory, a sleep disturbances, decreased appetite, disorientation, and hand and foot trembling etc (HSDB (2005)). Based on these results it was classified into Category 1 (nervous system) .
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour EC50= 0.75ppb of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=5.48 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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