GHS Classification Result

Chemical Name：2,4-Dinitrotoluene
CAS：121-14-2

Result：
ID: 33
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups, with its oxygen budget calculated at -144). Classified into Divisiton 6.1 (UN#1600 dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods). Commercial dinitrotoluene, which contains about 20% of 2,6-dinitrotoluene, starts to decompose at 250degC -- a process that continues at 280degC (Bretherick (J), 5th, 1998). The decomposition energy stands at about 85% of that of TNT (2,4,6-trinitrotoluene) (5.1kJ/g) (Bretherick (J), 5th, 1998), according to some reports.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified into Division 6.1 (UN#1600 dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not classified - - - - Classified into Division 6.1 (UN#1600 dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#1600 dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 71degC (ICSC, 1999), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bound to carbon and hydrogen. Classified into Division 6.1 (UN#1600 dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 324mg/kg calculated from the testing data of rat LD50 (oral route) of 268mg/kg (IUCLID (2000)), 568mg/kg (IUCLID (2000)), 650 mg/kg (IUCLID (2000)), 268 mg/kg (IUCLID (2000)), 270 mg/kg (IUCLID (2000)), 893 mg/kg (IUCLID (2000)), 400 mg/kg (IUCLID (2000))
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.51 (2004)): "mild irritation" (though exposure time is unknown).
3 Serious eye damage/eye irritation Not classified - - - - Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.51 (2004)): "mild irritation" (though exposure time is unknown).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests) and the absence of data on germ cell genotoxicity tests in vivo, described in CERI-NITE Hazard Assessment No.51 (2004).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Group 2B by IARC (1996).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in CERI-NITE Hazard Assessment No.51 (2004): The results of rat 3-generation reproduction studies suggest a decrease in the survival rate of newborns at dose levels toxic to parent animals; those of tests on male genital organs suggest atrophy of seminiferous tubules and severe spermatogenic disorder at dose levels causing adverse effects on body weight gain.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible, because of a lack of data, although specific target organs appear to be the blood and nervous systems, based on the evidence from animal studies including "cyanosis and dystonia, with rats showing higher sensitivity to lethal action than mice" (ATSDR 1998). Refer to GHS classification of "a mixture with dinitrotoluene isomers containing more than 70% of dinitrotoluene" (CAS#25321-14-6) made by the program. Commercial dinitrotoluene contains about 75% of 2,4- dinitrotoluene and 20% of 2,6- dinitrotoluene (CERI-NITE Hazard Assessment No.51 (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, blood, nervous system, testis) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, blood, nervous system, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "hepatocellular degeneration, hyperplasia of the bile duct epithelium, methemoglobinemia, anemia, demyelination of the brain stem and cerebellum, neuropathy, atrophy of testes" (CERI-NITE Hazard Assessment No.51 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Refer to GHS classification of "a mixture with dinitrotoluene isomers containing more than 70% of dinitrotoluene" (CAS#25321-14-6) made by the program. Commercial dinitrotoluene contains about 75% of 2,4- dinitrotoluene and 20% of 2,6- dinitrotoluene (CERI-NITE Hazard Assessment No.51 (2004)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours EC50=0.91mg/L of the algae (Chlorella) (CERI/NITE Hazard Assessment Report, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=1.98(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition of dinitrotoluene by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
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