GHS Classification Result

Chemical Name：Chlorpyrifos
CAS：2921-88-2

Result：
ID: 40
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though "Flammable" (ICSC (J) (1998))
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Flash point: 148degC (MSDS) and non-pyrophoric when in contact with air at a room temperature
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid or solid substances at 140degC are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although there is information that it corrodes coppers and brass (HSDB (Access on Mar. 2006)), there is no data based on set test methods.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		SPECIES: Rat ENDPOINT: LD50 VALUE: 135 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts
1 Acute toxicity （Dermal） Not classified - - - - It was set as the outside of Category since death is not observed in 2000mg/kg or less (Agricultural-Chemicals abstracts).Based on rat LD50 value >2000mg/kg.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Rat LC50 (4 hours) value is >0.2mg/L (Agricultural-Chemicals abstracts). But Category could not be specified only with this data, it was regarded that it cannot beclassified due to data insufficiency.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified (applicable to 72% Water dispersible granule) - - - - Since irritation was not observed in the skin irritation test of 72% granules hidrated agent on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Since change of the eye which is adapted for basis of irritation was not admitted in the test applied to the eye of the rabbit (Agricultural-Chemicals abstracts), it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category because the skin sensitization test by the Buehler method using guinea pigs showed 0% of positive rate (agrochemical abstract).
5 Germ cell mutagenicity Not classified - - - - Because there is a negative result in the mouse micronucleus test using bone-marrow cells from mice, which is an in vivo mutagenicity test using somatic cells (Agricultural-Chemicals abstracts), the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - - It was classified into Group E according to EPA(Office of Pesticide Programs List of Chemicals Evaluated for Carcinogenic Potential) and A4 (ACGIH, 2003) according to ACGIH. So it was set as the outside of Category.
7 Reproductive toxicity Not classified - - - - In the peroral administration reproduction study using rat, and the teratogenicity test using rat, mouse, and rabbit there was no reproductive toxicity in the dose causing general toxicity for parent animals (Agricultural-Chemicals abstracts). So it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (nervous system). Because the effects resulting from inhibition of cholinesterase activity and the symptoms suggesting the effects on the nervous system were observed in the oral administration tests using rats at the dosage within the guidance values for Category 1(Agricultural Chemical Abstracts).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, adrenal gland), Category 2 (eye) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system, adrenal gland)
H373: May cause damage to organs through prolonged or repeated exposure (eye) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since in the oral study using rat, paralysis of both legs and a tail, the decrease in activity of brain cholinesterase and adrenal zona fasciculata fatty vacuolization were observed within the given dose of the guidance value range of Category 1, and in the oral study using mouse, acute or subacute keratitis were observed within the given dose of the guidance value range of 2 Category (all were Agricultural Chemicals abstracts), they were classified into Category 1 (nervous system, the adrenal gland) and Category 2 (eye).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour LC50=0.000058mg/L of Crustacea (Ceriodaphnia) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD:0.2% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=2880 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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