GHS Classification Result

Chemical Name：Fenthion
CAS：55-38-9

Result：
ID: 41
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Flash point: 170degC (Bayer CropScience Co.).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not classified - - - - May burn but does not ignite readily.(HSDB(2006)) Even if it contacts air, it does not ignite (Bayer crop science corporations based on experience).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It does not become spontaneous combustibility even if it contacts water. Moreover, flammable and combustible gases are not produced (Bayer crop science corporations based on experience).
13 Oxidizing liquids Classification not possible - - - - No data available
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		SPECIES: Rat ENDPOINT: LD50 VALUE: 320 mg/kg, 509 mg/kg REFERENCE SOURCE: Agricultural Chemical Registration Data
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was classified into Category 4 based on rat LD50 = 2000 and 2000mg/kg (Agricultural-Chemicals abstracts).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into category 3 based on the lower value among rat LC50 = 1.2 and 0.8mg/L (Agricultural-Chemicalsd abstracts).
2 Skin corrosion/irritation Not classified - - - - Since "there was almost no irritation (Draze score 0.4)"in test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - It was classified out of Category based on the result of "no stimulativeness"in rabbit test (Agricultural-Chemicals abstracts).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category on the basis that no sensitization was found by the Maximization method using guinea pigs (agrochemical abstract).
5 Germ cell mutagenicity Not classified - - - - There are negative results from the in vivo multi-generation mutagenicity test using germ cells (dominant lethal test in mice) and the in vivo mutagenicity test using somatic cells (the chromosome aberration test using mouse bone-marrow cells, the mouse micronucleus test) (Agricultural-Chemicals abstracts). And there is no test with a positive result, the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - - Based on being classified into A4 according to ACGIH (ACGIH (1996)), it was classified as out of Category. In addition, there was no finding which indicates carcinogenicity also in the carcinogenic examination of mice (Agricultural-Chemicals abstracts).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there was increase of late resorptied embryo in the dose affecting to parent animals in pregnant period administration to rabbit, and there were decrease of conception rate, birth rate, survival rate, and nursing rate and the decrease of the average of the number of implantation and the average of the number of litters, and the increase of the number of the death, in the dose affecting to parent animals in the two-generation test of rat (Agricultural-Chemicals abstracts), it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (nervous system). Because effects on the nervous system (effects resulting from cholinesterase inhibition, blurred vision, staggering, not responding to stimuli and dyspnea) were observed (ACGIH (2001), JMPR (1980)). Cholinergic effects and effects on the nervous system, such as tremors, convulsions, decrease in locomotor activity, and salivation, have also been observed in tests using rats (Agricultural-Chemical abstracts, JMPR (1997)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		The cholinesterase inhibition and cholinergic symptoms (tremor, convulsion, etc.) in the repeated oral administration for three months using rat were observed, and because the dose are within the range of the guidance value of Category 1 (Agricultural Chemicals abstracts) they are classified into Category 1 (nervous system) .
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=0.00087mg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=4.09 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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