NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Tetramethyllead
CAS：75-74-1

Result：


ID:	46
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	The flash point is 37.8degC (c.c.) (ICSC, 2003) which is classified into Category 3. The list of the UN Recommendations on the Transport of Dangerous Goods does not contain "tetramethyl lead"; it only refers to "UN#1649 (Motor Fuel Anti-Knock Mixture)," the classes of which are all "toxic substances." A special provision, however, set forth that "substances with a flash point of less than 60degC should be labeled as "flammable liquid."
7	Flammable solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Not classified	-	-	-	-	Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 254degC (ICSC, 2004)
10	Pyrophoric solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Stable to water; insoluble (ICSC, 2004)
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine and chlorine
14	Oxidizing solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available. The list of the UN Recommendations on the Transport of Dangerous Goods does not contain "tetramethyl lead"; it only refers to "UN#1649 (Motor Fuel Anti-Knock Mixture)," the classes of which are all "toxic substances." A special provision set forth that "substances with a flash point of less than 60degC should be labeled as "flammable liquid."

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 105mg/kg representing the lower of the two testing data, 109mg/kg (DFGOT vol.15 (2001)) and 105mg/kg (DFGOT vol.15 (2001)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 (4 hours) value of 406ppm, calculated from the testing data of rat LC50 (inhalation of vapour) of 8.87ppm (1 hour) (ACGIH (7th, 2001)), was lower than 90% of the saturated vapor concentration (34,000ppm) under a saturated vapour pressure of 26mmHg (20degC) (equivalent to 3,500Pa at 20degC) (HSDB (2005)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available. Refer to other data on lead and its compounds (primarily organic lead)
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available Refer to other data on lead and its compounds (primarily organic lead)
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available. Refer to other data on lead and its compounds (primarily organic lead)
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Insufficient data available
6	Carcinogenicity	Not classified	-	-	-	-	Due to the fact that the substance is classified as Group 3 by IARC (2004).
7	Reproductive toxicity	Classification not possible	-	-	-	-	Insufficient data available (no data available on reproductive effects)
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the human evidence including "anorexia, nausea, vomiting, insomnia, tremor, debility, headache, aggression, melancholy, irritation, excitement, confusion, hallucination, acute psychosis (a few hours or a few days after the exposure), spasm, distraction, elevated temperature, coma" (DFGOT vol.15 (2001)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the human evidence including "hallucination, tremor, distraction, insomnia, delusion, headache, manic depression" (EHC 3 (1977)), and the evidence from animal studies including "tremor, chorea, excitement, an increase in mobility, histopathological changes in the central nervous system and liver" (DFGOT vol.15 (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96 hours LC50=0.11mg/L(Lead Tetramethyl Equivalent: 0.14mg/L) of the crustacea (Brown Shrimp) (EHC85, 1989).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and it was a metallic compound, and since an underwater action and bio-accumulation were unknown, it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）