GHS Classification Result

Chemical Name:Lead monoxide; Litharge
CAS:1317-36-8

Result:
ID: 48
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2002)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC, 2002)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC, 2002)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water; insoluble (ICSC, 2002)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to the absence of data, though being inorganic compounds containing oxygen.
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 2001-9 (2002)) "mild irritation". Refer to other data on lead and its compounds (primarily inorganic lead)
3 Serious eye damage/eye irritation Classification not possible - - - - No data available Refer to other data on lead and its compounds (primarily inorganic lead)
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available. Refer to other data on lead and its compounds (primarily organic lead)
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on many reports on the occupational exposure to lead compounds and the results of epidemiological studies: lead compounds induce chromosome aberration and micronucleated cells in human peripheral blood cells (SCE formation is also observed). Although no data are available on the evaluation of lead oxides per se, the results of epidemiological studies should be taken into account in view of their human germ cell mutagenicity. However, classification may not be possible, if based on the description in IARC 23 (1980): data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo are not available, and in vitro mutagenicity tests do not show strong positive results (in several indexes).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the classification by NTP (2005) (R: Lead and Lead Compounds), IARC (1987) (Group 2B: Lead and Inorganic Lead Compounds) and the Japan Society of Occupational Health (2B: Lead Compounds (Inorganic).
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in IARC 23 (1980): The results of epidemiological studies conducted at lead smelters suggest a significant increase in spontaneous abortion rates. (Workers in lead smelters may be exposed to lead fume, which is probably lead monoxide.)
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system, nervous system, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system, nervous system, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on human evidence including "the substance induces eye/skin/respiratory irritation and induces chemical bronchitis, pneumonia and pulmonary edema through inhalation of vapor" (ICSC (J) (2002)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Classification not possible due to lack of data
11 Hazardous to the aquatic environment (Long-term) Category 4 - - H413: May cause long lasting harmful effects to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since although acute toxicity is not reported within the aqueous solubility concentrations, it was a metallic compound, and the underwater action was unknown, it was classified into Category 4.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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