GHS Classification Result

Chemical Name：Diarsenic trioxide
CAS：1327-53-3

Result：
ID: 55
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC,1999)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC,1999)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,1999)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water - water solubility: 1.2 - 3.7g/100mL (20degC), (ICSC, 1999)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being inorganic compounds containing oxygen. Classified into Category 6.1 (UN#1561) by UN Recommendations on the Transport of Dangerous Goods
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 25mg/kg calculated from the testing data of rat LD50 (oral route) of 20mg/kg, 188mg/kg and 385mg/kg (EHC 224, 2001).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the evidence of "eyelid edema and corneal injury and opacity" (CERI Hazard Data 2001-8, 2001) from the rabbit skin irritation test, although the substance should be placed in Category 2A from the viewpoint of safety.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on heritable mutagenicity tests (dominant lethal tests) and germ cell mutagenicity tests in vivo (chromosome aberration tests), positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests) and the absence of data on germ cell genotoxicity tests in vivo, described in CERI Hazard Data 2001-8 (2002), Recommendations by Japan Society of Occupational Health (2000), and DFGOT Vol. 21 (2005). It should be noted, however, that the positive data on the chromosome aberration tests are based on epidemiological studies, and the substances concerned are not identified.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category K (as arsenic compounds and inorganics) by NTP (2005), Group 1 (as arsenic and arsenic compounds) by IARC (1987) and Category 1(as arsenic and arsenic compounds) by the Japan Society of Occupational Health.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the correlation between arsenic exposure and adverse effects on reproductive capacity (increased mortality of foetuses, newborns and children, a decrease in birthweights, an increased incidence of natural abortion, stillbirth and congenital malformation) observed in several epidemiological studies, the evidence of malformations in foetuses including cranioschisis and renal defect at dosing levels not toxic to dams in Syrian hamster teratogenicity tests, and the evidence of a decreased number of foetuses and skeletal malformations (although no data are available on toxicity to dams) in rat teratogenicity tests, described in CERI Hazard Data 2001-8 (2002) and EHC 224 (2001). It should be noted, however, that the results of the epidemiological studies do not provide sufficient information on confounding factors.
8 Specific target organ toxicity - Single exposure Category 1 (gastrointestinal tract, heart, skeletal muscle, respiratory system) Danger H370: Causes damage to organs (gastrointestinal tract, heart, skeletal muscle, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "severe digestive symptoms associated with vomiting and diarrhea, muscle spasm, cardiac abnormalities", nasal mucous membrane irritation (occasionally developing into nasal septum defect), pharynx and respiratory irritation" (IARC 23, 2004) and the evidence from animal studies including "dry vomiting and intestinal hemorrhage" (EHC 224, 2001).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, peripheral nervous system, immune system, respiratory system, liver, kidney, skin, blood vessels) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, peripheral nervous system, immune system, respiratory system, liver, kidney, skin, blood vessels) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "marked decrease in lymphocyte counts", "enlargement of the liver, loss of appetite, upper respiratory symptoms, skin lesion, peripheral neuropathy", "apparent damage to the liver and kidneys" (IARC 23, 2004), "gangrene caused by peripheral vascular disorder, a Taiwan case of black food disease induced by exposure to 20g of the substance in total over several years, calculated as arsenic" and "irritation to the surface of the body, skin, conjunctiva and nasal mucous membrane reported as effects of diarsenic trioxide" (CERI Hazard Data 2001-8, 2002) and the evidence from animal studies including "dehairing, eczema, squamous hyperplasia in the epidermis, hyperkeratosis, skin ulcer, incrustation" and "metaplasia in alveolar, tract and bronchial epithelia". The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96 hours LC50=20.2mg/L of the fish (Rainbow Trout) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 5 and bio-accumulation was low (BCF=5 (Existing Chemical Safety Inspections Data)), since it was a metallic compound and the underwater action was unknown, it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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