GHS Classification Result

Chemical Name:Hydrazine hydrate
CAS:7803-57-8

Result:
ID: 57
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Classification not possible, because of lack of data (though the substance is hydrazines, containing chemical groups associated with explosive properties). Classified into Division 6.1 and Class 8 (hydrazine hydrate refers to UN#2030 (aqueous solutions with a concentration of 37% by mass or more)) (UN Recommendations on the Transport of Dangerous Goods)
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
The flash point is 75degC (open cup flash test) (BUA205(1996)), which is classified into Category 4. Classified into Division 6.1, Class 8 and Packing Group I-III (UN Recommendations on the Transport of Dangerous Goods) (a special provision, however, set forth that "substances assigned to Packing Group I with a flash point of less than 60degC should be labeled as "flammable liquid") (hydrazine hydrate refers to UN#2030 (aqueous solutions with a concentration of 37% by mass or more)).
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not classified - - - - The substance is hydrazines and contains chemical groups associated with explosive properties. Classified into Division 6.1 and Class 8 (hydrazine hydrate refers to UN#2030 (aqueous solutions with a concentration of 37% by mass or more)) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not classified - - - - Classified into Division 6.1 and Class 8 (hydrazine hydrate refers to UN#2030 (aqueous solutions with a concentration of 37% by mass or more)) (UN Recommendations on the Transport of Dangerous Goods)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Inorganic compounds containing oxygen (but not halogen), with the oxygen bound to the water molecule of the hydrate (but not to other elements).
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Cannot be classified due to lack of data, though Merck (13th,2001) reports that, as for corrosivity to stainless steel, the substance does not act on V2A, SUS304 and SUS3, but should not be used for molybdenum like SUS316. Classified into "Class 8: Corrosive Substances" by the UN Recommendations on the Transport of Dangerous Goods. However, the category includes skin corrosivity, and it is unclear whether the substance is classified as "metal" corrosive (hydrazine hydrate refers to UN#2030 (aqueous solutions with a concentration of 37% by mass or more)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the LD50 value of 172mg/kg calculated from the testing data of rat LD50 (oral route) of 262mg/kg, 169mg/kg and 220mg/kg (the Ministry of Health, Labour and Welfare (2003)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in the report on 4-hour rabbit skin irritation test results (NITE Initial Risk Assessment No.73 (2005)): "Dermal application of 55% aqueous solution resulted in corrosion at the site of application in seven of the 11 test animals." The substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Classified as Category 1 in accordance with the technical guideline, given the fact that the substance is classified into Category 1A-1C of "skin corrosion/irritation."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the description in NITE Initial Risk Assessment No.73 (2005) of human health effects: "Hydrazine and its salts induce contact allergy in humans." Also due to the fact that hydrazine is classified as "Skin Sensitizing Substance: Group 2"* by the Japan Society for Occupational Health. *The category refers to the substance concerned and its compounds, but does not identify all substances causing respiratory/skin sensitization.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (mouse spot tests), described in CERI-NITE Hazard Assessment No.73 (2004) and EHC 68 (1987). As for the health hazards, refer to "ID56, Hydrazine, CAS: 302-01-2."
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment, given the absence of existing classification. As for the carcinogenicity, refer to "ID56, Hydrazine, CAS: 302-01-2."
7 Reproductive toxicity Classification not possible - - - - Insufficient data available As for the health hazards, refer to "ID56, Hydrazine, CAS: 302-01-2."
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, liver, kidney) Danger H370: Causes damage to organs (central nervous system, liver, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence: "Acute exposure to hydrazine hydrate has been known to adversely affect the central nervous system, liver and kidneys" (MOE Risk Assessment vol. 1 (2002)). Only those study reports specifying "hydrazine hydrate" as the test substance were used as a basis for classification. However, hydrazine monohydrate is easily formed when hydrazine (ID: 0056, CAS No.302-01-2) comes in contact with water. Hence, an aqueous solution of hydrazine often used in animal studies is also considered to be "hydrazine (mono)hydrate." Therefore, in evaluating hydrazine monohydrate, it is advised to refer to "hydrazine" (ID 0056, CAS No.302-01-2) as well.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, nervous system, gastrointestinal tract, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system, gastrointestinal tract, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "hepatic toxicity, neurological symptoms and heart symptoms," "jaundice, severe nephritis, renal tubular necrosis, glomerulonephritis and focal hepatocyte necrosis were observed at necropsy" (CERI-NITE Hazard Assessment No.78 (2004)), "gastritis, tremor, lethargy, loss of consistency in speech and behaviour, jaundice, readily palpable hepatic hypertrophy, elevated blood bilirubin/creatinine levels, albuminuria; severe renal tubular necrosis was found at autopsy" (IARC (1987)). Only those study reports specifying "hydrazine hydrate" as the test substance were used as a basis for classification. However, hydrazine monohydrate is easily formed when hydrazine (ID: 0056, CAS No.302-01-2) comes in contact with water. Hence, an aqueous solution of hydrazine often used in animal studies is also considered to be "hydrazine (mono)hydrate." Therefore, in evaluating hydrazine monohydrate, it is advised to refer to "hydrazine" (ID 0056, CAS No.302-01-2) as well.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 72 hours ErC50=0.19mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 2001).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=-2.07(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition of hydrazine by BOD: 2%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

MHLW Website (in Japanese Only)


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