GHS Classification Result

Chemical Name：m-Phenylenediamine
CAS：108-45-2

Result：
ID: 60
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as "flammable" by ICSC (2004). Classified into Division 6.1 (UN#1673(o-,m-,p-)) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 560degC (ICSC,2004).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 62-63degC (ICSC,2004), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 204mg/kg calculated from the testing data of rat LD50 (oral route) of 204mg/kg (CERI Hazard Data 98-29 (1999)), 650mg/kg (IARC 16 (1978)) and 280mg/kg (MOE Risk Assessment vol. 3 (2004)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (dermal route) of 1,100mg/kg (CERI Hazard Data 98-29 (1999)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the evidence of "mild to moderate irritation" from rabbit skin irritation tests (ACGIH (7th, 2001) and CERI Hazard Data 98-29 (1999)). Also based on the description of human health effects (ACGIH (7th, 2001), CERI Hazard Data 98-29 (1999) and MOE Risk Assessment vol. 3 (2004)): "skin irritant."
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 98-29 (1999)): "conjunctival injection and corneal opacity were observed." Also based on the description of human health effects (MOE Risk Assessment vol. 3 (2004)): "irritating to the eye." The substance is thus considered an eye irritant (though the severity of the effects is unknown). It should be placed in Category 2A from the viewpoint of safety if further subclassification is needed.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description in the report on guinea pig skin sensitization tests (CERI Hazard Data 98-29 (1999)): "Skin sensitization: positive." Also CERI Hazard Data 98-29 (1999), PATTY (4th, 1999) and MOE Risk Assessment vol. 3 (2004) contain descriptions that indicate a potential to cause skin sensitization in humans. Also due to the fact that the substance is classified into "Skin Sensitizing Substance" by the ad hoc committee of the Japanese Society of Occupational Allergy and "Skin Sensitizing Substance: Group 1" by the Japan Society for Occupational Health.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in CERI Hazard Data 98-29 (1999) and NTP DB (Access on March 2006).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 by ACGIH (2001) and Group 3 by IARC (1987).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of minor anomaly in filial generation at doses inducing maternal toxicity, described in MOE Risk Assessment vol. 3 (2004).
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system, respiratory system) Warning H371: May cause damage to organs (central nervous system, respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "airway edema" (IUCLID (2000)) and the evidence from animal studies including "acute pulmonary edema following dermal exposure" (RTECS (2004)), "clonic convulsion" and "cyanosis" (IUCLID (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. However, as the referenced study is rated as Priority 2, which does not meet the specified criterion 1b (iii), the substance is classified as Category 2 in accordance with the technical guideline.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver, kidney, urinary bladder), Category 2 (cardiovascular system, blood system, respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver, kidney, urinary bladder)
H373: May cause damage to organs through prolonged or repeated exposure (cardiovascular system, blood system, respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "abnormal reflex, hyperesthesia of the skin, pathological changes on the kidneys and liver," "death from sub-acute hepatatrophy with jaundice" (MOE Risk Assessment vol. 3 (2004)), "fibrosis in the lung, thickening of finger skin," "reflux esophagitis, leg edema, bradycardia, cardiac block, sclerodactylia, dilatation of peripheral vessels of fingers, fibrosis in the lung, esophageal dilatation," "death from hepatatrophy with jaundice" (IUCLID (2000)), "mucosal edema of the bladder, polypous swelling, cellular infiltration (eosinophilic leukocyte) in the bladder triangle area and cervix" (ACGIH (7th, 2001)), and the evidence from animal studies including "increased degeneration of the liver accompanied by pyknosis of hepatocytes" (ACGIH (7th, 2001)), "sedation, methemoglobinemia" (MOE Risk Assessment vol. 3 (2004)), "damage to the liver and central nervous system" (IUCLID (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=2.0mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals (2001) and others.).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=24(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 2%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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