GHS Classification Result

Chemical Name：Phenol
CAS：108-95-2

Result：
ID: 61
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified into Division 6.1 (UN#1671) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 715degC (ICSC, 2004)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 43degC (ICSC, 2004), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#1671) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value calculated from the testing data of rat LD50 (oral route) of 414mg/kg (MOE Risk Assessment vol. 1 (2002)), 512mg/kg (EHC 161 (1994)), 400mg/kg (EHC 161 (1994)), 340mg/kg (EHC), and 445mg/kg (EHC 161 (1994)). LD50=375 mg/kg
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the testing data of rat LD50 (dermal route) of 670mg/kg (EHC 161 (1994)). Likewise, based on the testing data of rabbit LD50 (dermal route) 850 mg/kg and 1,400 mg/kg (EHC 161 (1994)). The value of rat, which is lower than that of rabbit, is adopted for classification purposes.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the testing data of rabbit skin irritation tests (EHC 161 (1994)) and data on human health effects (EHC 161 (1994)): Corrosive to the skin. Subsequently classified into 1A-1C, due to lack of data for subclassification, although the substance should be placed in 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the testing data of rabbit eye irritation tests (EHC 161(1994)): Application of 10% glycerin solution or 5% aqueous solution causes complete corneal opacity, although numerical data are not available. The substance causes irreversible effects on the eye.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the negative results of the Mugnussen and Kligman skin sensitization tests on guinea pigs (EHC 191 (1994)), the MEST method using rats (NITE Initial Risk Assessment No.32 (2005)) and tests on human volunteers (NITE Initial Risk Assessment No.32 (2005)).
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on germ cell multi-generation mutagenicity tests and positive data on germ cell mutagenicity tests in vivo (chromosome aberration tests), described in CERI-NITE Hazard Assessment No.32 (2005) and NTP DB (Access on Dec., 2005)
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Group 3 by IARC (1999), Category A4 by ACGIH (2005) and Group D by IRIS (2002).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in CERI-NITE Hazard Assessment No.32 (2005): Birth rates decline at dose levels not toxic to parent animals (Narotsky and Kavlock, 1995)
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, cardiovascular system, kidney, nervous system) Danger H370: Causes damage to organs (respiratory system, cardiovascular system, kidney, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "adverse effects on the heart and blood vessels," "a significant increase in respiratory rate, dyspnea, irregular cardiac rhythm, cardiovascular shock, severe metabolic acidosis, methemoglobinemia, acute renal failure, nephropathy, dark urine, adverse effects on nervous systems (convulsions, etc.)" (CERI-NITE Hazard Assessment No.32 (2005)), "irregular heart rhythm" (EHC 161 (1994)), "arrhythmia, bradycardia" (ATSDR (1998)), and the evidence from animal studies including "strong suppression of pupillary reflex" (CERI-NITE Hazard Assessment No.32 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (cardiovascular system, liver, gastrointestinal tract, blood system, kidney, spleen, thymus, central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (cardiovascular system, liver, gastrointestinal tract, blood system, kidney, spleen, thymus, central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on human evidence including "an increase in mortality due to cardiovascular diseases" (CERI-NITE Hazard Assessment No.32 (2005)), "nonconjugated hyperbilirubinemia in newborns" (EHC 161 (2000)), "nausea, vomiting, diarrhea, gastralgia, hemolytic anemia, methemoglobinemia, glomerular degeneration, renal tubular necrosis; hemorrhage in papillary cells" (ATSDR (1998)), and the evidence from animal studies including "a significant decrease in red blood cell count, protein columns and necrosis of renal tubules; papillary hemorrhage, atrophy and necrosis of the spleen and thymus gland, hepatocellular vacuolar degeneration, severe adverse effects on the central nervous system (behavior observed in inclined plant tests), hepatopathy" (CERI-NITE Hazard Assessment No.32 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours LC50=3.1mg/L of the crustacea (Ceriodaphnia) (EU-RAR, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 85% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=1.46 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information