GHS Classification Result

Chemical Name：Hydrofluoric acid
CAS：7664-39-3

Result：
ID: 63
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - Non-combustible (Hydrogen Fluoride (ICSC, 2004))
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with self-reactivity
9 Pyrophoric liquids Not classified - - - - Non-combustible (Hydrogen Fluoride (ICSC, 2004))
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (Hydrogen Fluoride (ICSC, 2004))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not classified - - - - No data available, though being inorganic compounds containing fluorine. Based on the classification by the UN Recommendations on the Transport of Dangerous Goods (Division 6.1 and Class 8) (UN#1052 Anhydride and UN#1790 Hydrofluoric Acid).
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available - boiling point: 20degC (ICSC, 2004), test temperature: 55degC (Hydrogen Fluoride) No data available. Corrosivity to metals remains uncertain, though classified as "corrosive substances" (as the classification based on UN Recommendations on the Transport of Dangerous Goods includes "skin corrosivity") (UN#1790 (Hydrofluoric Acid)) (Hydrofluoric Acid).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available. Refer to sodium fluoride (CAS No.7681-49-4) for health hazards.
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LC50 value (4 hours) of 650ppm, calculated from the testing data of rat LC50 (1 hour inhalation of vapour) of 0.79mg/L (CERI Hazard Data 2001-46 (2002)), 1.915mg/L (CERI Hazard Data 2001-46 (2002)), 1.828mg/L (EU-RAR No.8 (2001)), 1.909mg/L (EU-RAR No.8 (2001)), 1.069mg/L (EU-RAR No.8 (2001)), 0.792mg/L (EU-RAR No.8 (2001)), 1.136mg/L (EU-RAR No.8 (2001)), 1.317mg/L (ATSDR (2003)), 1.069mg/L (PATTY (4th, 2000)) and 1.14mg/L (PATTY (4th, 2000)), was lower than 90% of the saturated vapor concentration (1,210,000 ppm) under a saturated vapour pressure of 122kPa (25degC) (Hydrogen Fluoride) (ICSC (2004)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the testing data of animal eye irritation tests (CERI Hazard Data 2001-46 (2002), EURAR No.8 (2001), ATSDR (2003) and PATTY 4th (2000)) and data on human health effects: Corrosive to the skin. The results of rabbit skin irritation tests suggest the formation of eschar (14 days after the 4-hour application of 5% aqueous solution), although the substance should be placed in Category 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the testing data of animal eye irritation tests (CERI Hazard Data 2001-46 (2002), EURAR No.8 (2001) and ATSDR (2003)) and high-concentration inhalation exposure tests (ATSDR (2003)): Irreversible effects and corrosivity are observed.
4 Respiratory sensitization Classification not possible - - - - Insufficient data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description of human health effects (CERI Hazard Data 2001-46 (2002)): "Allergic dermatitis is observed in workers occupationally exposed to the substance," which is thus considered to cause skin sensitization.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests) and the absence of data on germ cell genotoxicity tests in vivo, described in EU-RAR No.8 (2001).
6 Carcinogenicity Classification not possible - - - - Classification not possible, due to lack of data (No classification is available, though there are some data on the carcinogenicity; no evidence is observed of an increase in the incidence of osteosarcoma.) Refer to sodium fluoride (CAS No.7681-49-4) for health hazards.
7 Reproductive toxicity Classification not possible - - - - Insufficient data available Refer to sodium fluoride (CAS No.7681-49-4) for health hazards.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, pancreas) Danger H370: Causes damage to organs (respiratory system, pancreas) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "damage to the respiratory tract and lung, irritation to the nasal mucosa, conjunctiva and respiratory tract" (EU-RAR No.8 (2001)), "pulmonary hemorrhagic edema, bronchitis, pancreatic hemorrhage and necrosis" (CERI Hazard Data2001-46 (2002)) and the evidence from animal studies including "inflammation of the respiratory organs, pulmonary congestion, alveolar edema, damage to the nasal mucosa (necrosis, inflammation, cellular infiltration, effusion and hemorrhage in the epithelium and submucosal tissues)" (CERI Hazard Data 2001-46 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (bone, tooth, pituitary, thyroid, kidney, nervous system, liver, testis, bronchus) Danger H372: Cause damage to organs through prolonged or repeated exposure (bone, tooth, pituitary, thyroid, kidney, nervous system, liver, testis, bronchus) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on human evidence including "fluorosis of the bone (an increase in bone density, osseous deformity, exostosis, mottled enamel, loss of memory, pituitary/thyroid dysfunction" (CERI Hazard Data2001-46 (2002)), and the evidence from animal studies including "degeneration and necrosis of renal tubules, cerebrospinal dysfunction (a disturbance of conditioned reflex, prolongation of the latent time before the reflex occurs following stimulation), degeneration of nerve cell synapses, diffuse focal necrosis of hepatocytes, fatty degeneration of the hepatic parenchyma, periportal fibrosis, inflammation of the epithelium of the scrotum, ulcer on the scrotum, degenerative changes in the testes" (CERI Hazard Data2001-46 (2002)), "atrophy and edema in the bronchial mucosa, peribronchial hyperplasia" (EU-RAR No.8 (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96 hours EC50=10.5mg/L of the crustacea (Mysid Shrimp)) (EU-RAR (2002) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although the acute toxicity was Category 3, judging from the NOEC=14.1mg/L during 21 days of the crustacea (Daphnia magna) (EU-RAR, 2002), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information