GHS Classification Result

Chemical Name:Endosulfan
CAS:115-29-7

Result:
ID: 65
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible, substance itself does not burn. (HSDB (2006))
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible, substance itself does not burn.(HSDB(2006)) It does not ignite, even if it contacts air. ((Bayer Crop Science Corporation) based on experience)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible, substance itself does not burn.(HSDB(2006)) It does not generate heat, even if it contacts air. ((Bayer crop science corporations) based on experience)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on LD50 = 37.4mg/kg calculated by statistical calculations from 14 LD50 values of a rat (9.6 to 355 mg/kg)(EHC 40 (1984), JMPR (1965, 1998), PIM 576 (2000)), it was set as Category 2.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 3. Based on both two rat LD50 values (1000 and 681mg/kg) (Agricultural-Chemicals abstracts) were classified into Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on that both male rats LC50 = 0.0346mg/L and female LC50 = 0.0126mg/L (Agricultural-Chemicals abstracts) were in the scope of category 1, it was classified into category 1.
2 Skin corrosion/irritation Not classified - - - - Based on the rabbit skin irritation test data where Draze score was zero(JMPR (1998)) , it was considered to "have no irritation" and classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - From the result (JMPR (1998)) of "not irritayting to eyes" by the eye irritation test using a rabbit, it was classified out of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category because of the "negative" result (agrochemical abstract) by the skin sensitization test (Maximization method, GLP) using guinea pigs.
5 Germ cell mutagenicity Not classified - - - - Because the mouse in vivo micronucleus test result is negative (Agricultural-Chemicals abstracts), the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - - Based on being classified into A4 according to ACGIH (ACGIH (2001)), it was classified as out of Category. In addition, the increase of the generating frequency of the tumor relevant to administration is not observed in rat chronic toxicity and carcinogenicity annexation examination (1989) and mouse carcinogenicity tests (1988) (Agricultural-Chemicals abstracts).
7 Reproductive toxicity Not classified - - - - In the two-generation reproduction toxicity study of rat, except that there was the reduced weight gain in the maternal animals with highest dose, there was no effect for breeding and children (Agricultural-Chemicals abstracts). Moreover, there was no teratogenicity in the administration during pregnant period to rabbit and rat (Agricultural-Chemicals abstracts), and they were considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 1 (nervous system). Based on the reports of effects on the nervous system, such as convulsions, disturbance of consciousness, dyspnea, in humans (ATSDR (2000), JMPR (1998)) and of effects on the nervous system, such as decrease in locomotor activity, convulsions, salivation, tremors, dyspnea, at the dosage lower than the guidance level for Category 1in an acute oral test in rats (40, 50 and 100mg/kg) and in an inhalation toxicity study in rats (0.0123, 0.0036mg/L) (EHC40 (1984), ATSDR(2000), JMPR reports).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney), Category 2 (liver) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (kidney)
H373: May cause damage to organs through prolonged or repeated exposure (liver)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since in the 90-day repeated oral administration study of rat, the observation of the degeneration of the proximal tubule within the limits of the guidance value (3.85mg/kg) of Catgory 1and the acknowledgementof the hepatocellular degeneration Agricultural Chemicals abstracts) within the limits of the guidance value (23.41mg/(kg) in Category 2, they were classified into Category 1 (kidney) and Category 2 (liver). [Notes] As additional study, on the administration test to male rats for 30 days about 3 times as much dose of the 90-day repeated oral administration study, "Although the observation of the increase in the size and number of a lysosome in the proximal renal tubule, it is reversible change and the obstacle to the renal cell was not observed. On liver inspections, abnormalities in hepatic parenchyma and Kupffer cells were not observed, and liver weight increase was considered to be a result of the adjustment reaction relevant to the xenobiotic metabolism mechanism. " This conclusion has been obtained. Moreover, no effect is showed by the chronic toxicity test (prescribed for 104 weeks by the 3.8mg/kg highest dosage) in rat. (Agricultural Chemicals abstracts)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=0.2microg/L of Crustacea (Brown shrimp) (EHC40, 1984).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.83(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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