GHS Classification Result

Chemical Name：Pentachlorophenol
CAS：87-86-5

Result：
ID: 67
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no atom groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC,2003)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no atom groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC,2003)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,2003)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine), with the oxygen and chlorine bound to carbon and hydrogen, respectively (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 110 mg/kg calculated from the testing data of rat LD50 (oral route) of 27mg/kg (IARC 53, 1991), 175mg/kg (IARC 53,1991), 80mg/kg (ATSDR, 2001), 120mg/kg (ATSDR, 2001), 50mg/kg (ATSDR, 2001), 180mg/kg (ATSDR, 2001), 220mg/kg (ATSDR, 2001), 230mg/kg (ATSDR, 2001), 80mg/kg (ATSDR, 2001), 120mg/kg (ATSDR, 2001), 150mg/kg (ACGIH 7th, 2001), 200mg/kg (ACGIH 7th, 2001), 150mg/kg (EHC 71, 1987), 135mg/kg (EHC 71, 1987), 205mg/kg (EHC 71, 1987), 78mg/kg (EHC 71, 1987), 65mg/kg (EHC 71, 1987), 27mg/kg (EHC 71, 1987), 83mg/kg (EHC 71, 1987), 146mg/kg (EHC 71, 1987) and 175mg/kg (EHC 71, 1987).
1 Acute toxicity （Dermal） Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 40mg/kg calculated from the testing data of rabbit LD50 (dermal route) of 60mg/kg (PATTY 4th, 1999), 130mg/kg (PATTY 4th, 1999) and 40mg/kg (PATTY 4th, 1999).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the descriptions in CERI Hazard Assessment 2000-32 (2001), NTP TR483 (1999), ATSDR (2001), ACGIH (7th, 2001), EHC 71 (1987) and PATTY (4th, 1999), suggesting its apparent irritability of an unknown degree, and due to the fact that the substance is classified as "Xi (irritant)" by EU Risk Phrase.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the descriptions in CERI Hazard Assessment 2000-32 (2001), NTP TR483 (1999), ATSDR (2001), EHC 71 (1987), PATTY (4th, 1999) and ACGIH (7th, 2001): "Dusts are particularly irritating to the eyes and nose at concentrations greater than 1 mg/m3.", suggesting its apparent irritability of an unknown degree, and due to the fact that the substance is classified as "Xi (irritant)" by EU Risk Phrase, although the substance should be placed in Category 2A from the viewpoint of safety.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Not classified - - - - Based on the negative data on heritable mutagenicity tests (dominant lethal tests) and in somatic cell mutagenicity tests in vivo (micronucleus and mouse spot tests) and the absence of data on germ cell mutagenicity tests in vivo, described in CERI Hazard Data 2000-32 (2001), IARC 53 (1991), NTP DB (Access on September 2005), EHC 71 (1987), ATSDR (2001), NTP TR-349 (1989) and DFGOTvol.3 (1992).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category A3 by ACGIH (2001), Group 2B by IARC (1991) and Category B2 by EPA (1993).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the descriptions from CERI Hazard Data 2000-32 (2001), IARC 53 (1991) and ATSDR (2001) regarding the evidence of foetal lethality etc. at dosing levels not toxic to dams and the following evidence not accompanied by descriptions of toxicity to dams: decreased conception rates in rat two-generation reproduction tests, decreased second-mating/birth rates in mink reproductive toxicity tests, changes in the sex ratio of newborns in rat reproductive toxicity tests and malformation of the skeleton and soft tissues in rat teratogenicity tests.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, heart), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system, heart)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence inlcuding "ataxia, fatigue, headache, dizziness, disorientation, anorexia, nausea, vomiting, dyspnea, high fever, tachycardia, debility, fever and perspiration" (EHC 71, 1987), "conjunctivitis, corneal opacity, corneal anesthesia, slight mydriasis, tachycardia, tachypnea, airway irritation, hypertrophy of the liver, metabolic acidosis" (ACGIH, 7th, 2001), "excessive inhalation causes muscular relaxation and circulatory debility and may cause death" (MOE Risk Assessment Vol. 1, 2002) and "cardiopathy and cardiac failure" (ICSC (J) , 2003).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, nervous system, respiratory system, heart, liver, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood system, nervous system, respiratory system, heart, liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "aplastic anemia" (MOE Risk Assessment Vol. 1, 2002), "skin/nasal mucous membrane/airway irritation, chloracne, depression, headache, porphyria cutanea tarda, changes in hepatic/renal functions, insomnia, dizziness" (EHC 71, 1987) and "endogastritis, pulmonary congestion, brain edema, cardiac dilatation, degeneration of centrilobular degeneration in the liver, mild renal tubule degeneration" (Patty 4th, 1999) and the evidence from animal studies including "brown pigmentation of the liver and kidneys" (MOE Risk Assessment Vol. 1, 2002). The effects on the liver/kidneys and on the blood systems of experimental animals were observed at dosing levels within the guidance value ranges for Category 1 and Category 2, respectively.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=15-30microg/L of the fish (Zebrafish) (MOE Risk Assessment vol. 1, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=224(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 1%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information