GHS Classification Result

Chemical Name：Methacrylic acid
CAS：79-41-4

Result：
ID: 70
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is 68degC (c.c.) (ICSC (2004)), which is classified into Category 4.
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though containing unsaturated bonds. Those containing stabilizers are classified into Class 8 (UN#2531) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 400degC (NFPA(13th,2002)).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data, though the substance acts on metals according to ICSC (2004). Those containing stabilizers are classified into Class 8 (UN#2531) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 1,210mg/kg calculated from the testing data of rat LD50 (oral route) of 1,060mg/kg (MOE Risk Assessment vol. 2 (2003)), 1,320mg/kg, 2,260mg/kg and 2,224mg/kg (EU-RAR No.25 (2002)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 (dermal route) value of 500-1,000mg/kg representing the lower of the two testing data, 500-1,000mg/kg (EU-RAR No.25 (2002)) and 2,000mg/kg (CERI Hazard Data 96-34 (1997)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Because the rat LC50 (4-hour inhalation exposure) value of 7.1mg/L (equivalent to 2,000ppm) (EU-RAR No.25 (2002)) exceeded the saturated vapour concentration (900ppm) under a saturated vapour pressure of 0.09kPa (20degC), the substance was considered as "mist exposure."
2 Skin corrosion/irritation Category 1A Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on a skin irritation test with a rabbit (CERI-NITE Hazard Assessment No.92 (2005)): "Corrosion was observed after 3 minute open application." Classified into Category 1A in accordance with the criteria for subclassification.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on rabbit eye irritation tests performed in accordance with OECD Test Guideline 405 (CERI-NITE Hazard Assessment No.92 (2005)): "Corneal opacity/irritation and conjunctival injection/chemosis were observed in all test animals at 24 hours," "corneal opacity and corneal/conjunctival irritation persisted through day 7, with chemical burn, corneal epithelial necrosis/loss and empyema of the anterior chamber of eyeball noted." The substance is classified as Category 1, given Category 1A of skin irritation.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on no evidence of sensitization from Buehler tests in guinea pigs (CERI-NITE Hazard Assessment No.92 (2005)), no positive results in Polak adjuvant tests and no epidemiological finding suggesting skin sensitization in humans. Also based on a report concluding "human epidemiological studies and animal studies provide no evidence of skin sensitization" (EU-RAR No.25 (2002)).
5 Germ cell mutagenicity Classification not possible - - - - Insufficient data available (no data available on in vivo mutagenicity/genotoxicity tests) As for germ cell mutagenicity, refer to "ID204, Methyl Methacrylate, CAS: 80-62-6."
6 Carcinogenicity Classification not possible - - - - Based on expert judgment, given the absence of existing classification (though epidemiological data are available). As for carcinogenicity, refer to "ID204, Methyl Methacrylate, CAS: 80-62-6."
7 Reproductive toxicity Classification not possible - - - - Insufficient data available As for reproductive/developmental toxicity, refer to "ID204, Methyl Methacrylate, CAS: 80-62-6."
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies (EU-RAR No.25 (2002)): "respiratory irritation," suggesting a potential for respiratory tract irritation.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver, kidney, adrenal gland), Category 2 (respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver, kidney, adrenal gland)
H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "tachycardia, low blood pressure, excessive reaction with nitroglycerin, low body temperature, weak reaction to heating/ultraviolet rays, pathological changes of Ashner reflex, acrocyanosis and tremor of fingers" (EU-RAR No.25 (2002)), and the evidence from animal studies including "changes in hepatic enzymes, changes in electrolyte, reduced liver/adrenal weights, atrophy of liver/kidneys/adrenal gland, degeneration of nasal olfactory epithelium" (CERI-NITE Hazard Assessment No.92 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (liver, kidneys, adrenal) and Category 2 (respiratory organs).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 72 hours ErC50=14mg/L of the algae (Selenastrum) (CERI/NITE Hazard Assessment Report, 2005).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 91% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=0.93 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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