GHS Classification Result

Chemical Name：2-isopropyloxyphenyl N-methylcarbamate
CAS：114-26-1

Result：
ID: 72
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available by regulated examination methods, though "Flammable under specific conditions" (ICSC(J) (1994))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid or solid substances at 140degC are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous or solid substances at 55degC (test temp.) are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: :83mg/kg; REFERENCE SOURCE: ACGIH 7th, 2001)
1 Acute toxicity （Dermal） Classification not possible - - - - Category was not able to be specified only from Rat LD50 value: >2400mg/kg (ACGIH 7th, 2001) data. So it cannot be classified since data is insufficient.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Calculated based on rat LC50 (1 hour) value : 1.44mg/L (4-hour equivalent 0.36mg/L) (RTECS, 2005, HSDB, 2005), LC50 (4 hours, aerosol) value : >0.5mg/L (IUCLID, 2000, HSDB, 2005), LC50 (4 hours, dust) value: 0.654mg/L (IUCLID, 2000) and >0.654mg/L (HSDB, 2005). Since the calculation was lower than lowest values, 0.36mg/L of lowest values was adopted and set it to category 2.
2 Skin corrosion/irritation Classification not possible - - - - There are statements that there was no skin irritation on rabbits (IUCLID (2000)), and that there was no skin irritation on rats (HSDB (2005)). But it cannot be classified as out of Category because there was no statement which clearly negates hazard in Priority 1. Therefore it was unclassified.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It was set as Category 2B from description that very slight stimulativeness was acknowledged in the eye of the rabbit of IUCLID (2000).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - IUCLID (2000) describes that no sensitization was found in the Buehler test and the maximization test, which use guinea pigs. However we classified this as not out of category but uncategorizable because there was no description that clearly negates hazardousness in Priority 1.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because there is a positive result from the dominant lethal test in mice, which is an in vivo multi-generation mutagenicity test using germ cells (RTECS, 2005), the substance was classified as Category 1B.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it was classified into A3 according to ACGIH (ACGIH 7th, 2001), it was set as Categoyr 2.
7 Reproductive toxicity Not classified - - - - Because of the description there was no obvious reproductive toxicity of maternal animal in pregnant oral administration test to rat with the dosage of occuring general toxicity (IRIS (2005)), without the description of general toxicity to parent animal but with the description of not observing the obvious reproductive toxicity in 3-generation reproduction study to rat, they were considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 (nervous system) because it is reported in ACGIH (7th, 2001) and IRIS (2005) that inhibition of cholinesterase activity and neurological symptoms associated with it were observed in human exposure cases.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (urinary bladder) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (urinary bladder) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Due to the descriptions in ACGIH (7th, 2001) that the cholinesterase activities inhibition accompanied by symptom for 28 days using the rat in oral administration study and reduction in brains cholinesterase activities was observed in the 12-week inhalation exposure test using rats with each dose of the guidance value range of Category 1, and the observation of the hyperplasia (urothelial hyperplasia) of the urinary tract epithelium of a bladder with the given dose of the guidance value range of Category 2 in the chronic toxicity study for two years using the rats of IRIS (2005), they were classified into Category 1 (nervous system) and Category 2 (bladder).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour 34microg/L of Crustacea (Amphipod) (HSDB, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 5% (existing chemical safety inspections data)), though supposed less bioaccumulative (log Kow=1.52 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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