GHS Classification Result

Chemical Name：Carbaryl
CAS：63-25-2

Result：
ID: 73
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible, substance itself does not burn. (HSDB (2006))
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It does not ignite, even if it contacts air. (Bayer Crop Science Corporation based on experience) Non-combustible, substance itself does not burn.(HSDB(2006))
11 Self-heating substances and mixtures Not classified - - - - It does not generate heat, even if it contacts air (Bayer crop science corporations based on experience). Non-combustible, substance itself does not burn(HSDB(2006)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - There are no chemical groups associated with peroxide present in the molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Since 23 rat LD50 values (JMPR (1965), EHC153 (1994)) corresponded as a classification target and a clear sex difference between each value was not seen, it was set as Category 4 based on 425 mg/kg obtained by statistical calculations.
1 Acute toxicity （Dermal） Classification not possible - - - - Rat LD50 >4000mg/kg, rabbit LD50 >2000mg/kg (EHC 153 (1994)). There is no more information and it cannot be classified.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Rat LC50 >0.792mg/L (EHC 153 (1994)). There is no information beyond it, and so it cannot be classified.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Transient erythema was observed in the test on rabbits (EHC 153 (1994)) and mild irritation and warmth appeared in the skin in exposure test to humans, they recovered in several hours (PIM 147 (1997), ACGIH (2001)). Threfore it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Although a spot cornea necrosis and iritis were also described by the test using a rabbit, irritation having been acknowledged in the conjunctival as a general conditions, and having recovered in 2-3 days (EHC 153 (1994)). So it was set as Category 2B. In addition, it is reported that although mild palpebral edema and cornea stimulus were also seen with human, the recovery was prompt (PIM 147 (1997)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category on the basis that several skin sensitization test using guinea pigs found no or little sensitization (EHC 153 (1994)).
5 Germ cell mutagenicity Not classified - - - - The results of the in vivo chromosome aberration test using rat bone-marrow cells, the in vivo micronucleus test using mouse bone-marrow cells (somatic cell in vivo mutagenicity test) (Agricultural-Chemicals abstracts), and the dominant lethal test in mice (multi-generation mutagenicity test) (EHC 153(1994)) are all negative. So the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - - It is classified into A4 in the evaluation by ACGIH (1996) into the group 3 in the evaluation by IARC (1987), respectively. Based on these category results, it was set as the outside of Category.
7 Reproductive toxicity Not classified - - - - The two generation reproduction study of rat, and the teratogenicity test by administration during organogenetic period using rat and rabbit are carried out (Agricultural-Chemicals abstracts). Since in each study, the adverse effects was not observed in reproductive indecis as reproductive function or reproductive potencial etc., and fetal development including teratogenicity, they were considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are case reports of severe neurological symptoms with occasional muscarinic or nicotinic symptoms, as well as cholinesterase inhibition when the substance is ingested by humans (EHC 153 (1994), PIM 147 (1997)). Moreover, it is reported that there was a strong correlation between fatality and cholinesterase inhibition in a sheep oral administration study of 300-1000mg/kg (EHC 153(1994)). The substance was classified as Category 1 (nervous system) based on these results.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the influence to the motor behavior, such as the influence to the autonomy, the tremor and the neuromuscular etc owing to the inhibition of the cholinesterase activities by a repeated doses in rat were observed in the 30 mg/kg/day administration group (Agricultural Chemicals abstracts), it was classified into Category 2 (nervous system) as compared with the guidance value.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour EC50=5.6microg/L of Crustacea (Daphnia magna) (EHC 153, 1994).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 71% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=2.36 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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