GHS Classification Result

Chemical Name：Dimethyl 2,2-dichlorovinyl phosphate; Dichlorvos
CAS：62-73-7

Result：
ID: 76
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 177degC (open cup flash test) (NFPA (13th, 2002))
7 Flammable solids Not classified - - - - Classified as "flammable" by ICSC (2004). Classified into Division 6.1 (UN#3018 (Organophosphorous Pesticide, liquid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not classified - - - - No data available, though containing unsaturated bonds. Classified into Division 6.1 (UN#3018 (Organophosphorous Pesticide, liquid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not classified - - - - Classified into Division 6.1 (UN#3018 (Organophosphorous Pesticide, liquid, toxic) (ICSC,2004)) (UN Recommendations on the Transport of Dangerous Goods)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 10,000mg/L (20degC), HSDB (2006))
13 Oxidizing liquids Not classified - - - - No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 UN Recommendations on the Transport of Dangerous Goods (UN#3018 (Organophosphorous Pesticide, liquid, toxic) (ICSC,2004)).
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#3018 (Organophosphorous Pesticide, liquid, toxic) (ICSC, 2004)) (UN Recommendations on the Transport of Dangerous Goods)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LD50 (oral route) value of 56mg/kg in the acute toxicity study with rats (Agricultural Chemical Registration Data (2003)).
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on LD50 (dermal route) value of 75mg/kg in the acute toxicity study with rats (Agricultural Chemical Registration Data (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data on acute toxicity by vapour exposure.
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because the LC50 values of 50.3ppm, 38ppm, 72ppm, 57.9ppm and 49.4ppm, calculated respectively from the testing data of rat LC50 (1 hour) of 0.455mg/L (EHC 79 (1988)), LC50 (4 hours) of 0.34mg/L (EHC 79 (1988)), 0.65mg/L, 0.523mg/L and 0.447mg/L (PATTY (4th, 1999)), exceeded the saturated vapour concentration (20.9ppm) under a saturated vapour pressure of 0.0158mmHg (25degC; equivalent to 2.11Pa), the substance was considered as "mist exposure" and was classified based on the LC50 of 0.266mg/kg (4-hour inhalation of dust/mist).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (Agricultural Chemical Registration Data (2003)): The substance produced mild reversible irritation of the skin.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description in the report on rabbit eye irritation tests (Agricultural Chemical Registration Data (2003)): The substance induced corneal and conjunctival irritation. The reactions resolved on day 5.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Skin sensitization studies (Maximization Tests) in guinea pigs gave positive results (Agricultural Chemical Registration Data (2003)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), germ cell mutagenicity tests in vivo (chromosome aberration tests) and somatic cell mutagenicity tests in vivo (micronucleus tests, chromosome aberration tests), described in NTP DB (Access on Apr., 2006), IARC 53 (1991), ATSDR (1997), DFGOT Vol.4 (1992) and CERI-NITE Hazard Assessment No.86 (2005). Moreover, Agricultural Chemical Registration Data (2003) report on the substance giving negative data on in vitro chromosome aberration tests.
6 Carcinogenicity Not classified - - - - There was no increase in tumor incidence in carcinogenicity studies in rats using oral and inhalation routes of exposure (Agricultural Chemical Registration Data (2003)). Also due to the fact that the substance is classified as Category A4 by ACGIH (2001).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on parental reproduction and pup development up to doses producing parental toxicity, described in Agricultural Chemical Registration Data (2003), IARC 53 (1991), EHC 79 (1988), ATSDR (1997) and CERI-NITE Hazard Assessment No.86 (2005).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the report of single dose studies in rats and mice (Agricultural Chemical Registration Data (2003)): exophthalmos, excessive lacrimation, salivation, generalized myofasciculation and tremor were observed. These effects were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In animal studies with rats and dogs, effects on nervous system caused by cholinesterase inhibition, diffuse vacuolar degeneration, fatty degeneration and swelling of hepatocyte and mild bile stasis were reported (Technical Reports for Agricultural Chemical Registration (2003)). These effects were observed within the guidance values for Category 2 in the repeated-dose study. Based on these data, the substance was classified as Category 2 (nervous system, liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.000019mg/L of the crustacea (Mysid Shrimp)) (CERI/NITE Hazard Assessment Report, 2005).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=1.47(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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