GHS Classification Result

Chemical Name：4,6-Dinitro-o-cresol
CAS：534-52-1

Result：
ID: 78
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups, with its oxygen budget calculated at -97). Classified into Division 6.1 (UN#1598) (UN Recommendations on the Transport of Dangerous Goods)
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as "flammable" by ICSC (2004). Classified into Division 6.1 (UN#1598) (UN Recommendations on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not classified - - - - No data available, though the substance contains chemical groups associated with explosive properties that contain nitro groups. Classified into Division 6.1 (UN#1598) (UN Recommendations on the Transport of Dangerous Goods)
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 340degC (ICSC, 2004).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 87.5degC (ICSC, 2004), test temperature: 140degC)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 25mg/kg calculated from the testing data of rat LD50 (oral route) of 25mg/kg, 31mg/kg, 50mg/kg and 85mg/kg (EHC 220 (2000)).
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 (dermal route) value of 200mg/kg representing the lowest of the testing data, rat LD50 of 200mg/kg, 600mg/kg (EHC 220 (2000)) and rabbit LD50 (dermal route) of 1,000mg/kg (EHC 220 (2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 (4-hour inhalation of dust/mist) value of 0.23mg/L (EHC 220 (2000).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in the report on rabbit skin irritation tests (DFGOT vol.19 (2003)): "The substance causes moderate irritation."
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on rabbit eye irritation tests (EHC 220 (2000)): "Corrosive."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive data on multi-generation mutagenicity tests (dominant lethal tests), described in EHC 220 (2000), ATSDR (1995) and NTP DB (Access on Apr., 2006).
6 Carcinogenicity Classification not possible - - - - Classification not possible given the insufficiency of data, along with the absence of existing classification.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of resorption and malformation at doses causing parental toxicity, described in ATSDR (1995), EHC 220 (2000) and DFGOT vol.220 (2000).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, liver), Category 2 (respiratory system) Danger
Warning 		H370: Causes damage to organs (nervous system, liver)
H371: May cause damage to organs (respiratory system) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. 		Based on the human evidence including "coma, headache, nausea or vomiting" (RTECS (2004)), "pulmonary/brain edema" (HSDB (2003)), and the evidence from animal studies including "myospasm, tremor, ataxia, debility, hepatic swelling with hemorrhage and necrosis" (ATSDR (1995)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory system, liver, kidney), Category 2 (thymus, spleen) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system, respiratory system, liver, kidney)
H373: May cause damage to organs through prolonged or repeated exposure (thymus, spleen) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "headache, fever, hyperhidrosis, abnormal thirst, short of breath, coughing, vomiting, hyperpnoea, emotional anxiety, debility, yellow discoloration of skin/hair/sclera/conjunctiva, pulmonary edema, stupor and coma," "regressive degeneration occurs in the hepatic parenchyma and renal tubules," "neurotoxicity manifests as toxic psychosis and brain edema diagnosed based on occasional spasm; peripheral neuropathy, asthenia, fatigue and autonomic hypertonia have also been reported" (PATTY (4th, 1999)), and the evidence from animal studies including "increased BUN," "fatty degeneration of the liver," "atrophy or hyperplasia of the thymus and spleen" (ATSDR (1995)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (liver, kidneys) and Category 2 (thymus, spleen).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.066mg/L of the fish (Rainbow Trout) (EHC220, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=0.7(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 4%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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