Chemical Name：Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl-
CAS：4098-71-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	From four results (MOE Risk Assessment the 3rd volume (2004), CERI Hazard Data (2000) and ACGIH (2001)) obtained from rat three examinations, it was set as Category 4 based on LD50= 1097mg/kg calculated with the technical guide.
1	Acute toxicity （Dermal）	Category 4		Warning	H312: Harmful in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	It was set as Category 4 based on LD50 = 1060mg/kg which is the lower value of rabbit LD50 = 1060 - 4780 mg/kg (CERI Hazard Data (2000)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Since the saturated vapor pressures concentrations pressure of this product is 0.396ppm, it is presumed that LC50 value acquired by all inhalation study was acquired in mist conditions. Based on LC50 = 0.786mg/L calculated by the technical guide using three test results of rats (CERI Hazard Data (2000), MOE Risk Assessment(2004), and ACGIH (2001)), it was set as Category 3.
2	Skin corrosion/irritation	Category 1A-1C		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Since there are statements about severe irritation on humans (HSDB (2003)) and corrosivityity and severe necrosis and edematous on rabbits (IUCLID (2000), CERI Hazard Data (2000)); it was classified as Category 1A-1C.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	Based on that this product is a skin corrosive substance, and that the strong eye stimulus with human is reported (CERI Hazard Data (2000), MOE Risk Assessment The 3rd volume (2004), IUCLID (2000)), and that moderate to severe irritation with rabbit is reported (CERI Hazard Data (2000), ACGIH (2001)), it was referred to as Category 1.
4	Respiratory sensitization	Category 1		Danger	H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled	P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ...	Classified as Category 1 on the basis that sensitization is reported in humans (CERI Hazard Data (2000)), and that this is listed as a respiratory sensitization in MOE Risk Assessment vol. 3 (2004), ACGIH (2001) and ALGY Society (2004).
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Classified as Category 1 on the basis that sensitization is reported in humans (CERI Hazard Data (2000)), and the development of skin sensitization is reported in mice and guinea pigs (CERI Hazard Data (2000), ACGIH (2001), and IUCLID (2000)).
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Although there are negative in vitro test results (CERI Hazard Data (2000)), it was decided that the substance could not be classified by the technical guidelines because there is no in vivo data.
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Classification not possible	-	-	-	-	Classification not possible due to lack of data
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified as Category 3 (airway irritant). Based on the reports of the substance causing irritation to nasal mucosa in rats (IUCLID (2000)) and of it causing strong irritation to airways in humans (CERI Hazard Data (2000)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (lung)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (lung)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was classified into Category 1 (lung) based on the report (CERI Hazard Data (2000)) of pulmonary edema within the guidance dose value of Category 1in rat.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available