GHS Classification Result

Chemical Name：Ethylene Thiourea
CAS：96-45-7

Result：
ID: 91
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since the melting point, boiling point, the flash point, etc. are measured at the temperature of 70 degC or more (ICSC (J) (1994) etc.), the ignition point is judged to be 70 degC or more.
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on rat LD50 = 604.8 mg/kg obtained by applying the calculation formula to LD50 value of the rat 4 examinations (545, 900, 940, and 1832 mg/kg) (DFGOT vol.11 (1998) and CERI Hazard Data (2002)), it was set as Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - There is a report of one examination case. But there is no statement on such as the strength of a stimulus. So it cannot be classified because of insufficient data.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		It was set as Category 2B based on the slight stimulative statement (CERI Hazard Data (2002)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Classified as Category 1 because several patch tests in humans and the Maximization Test using guinea pigs result positive (DFGOT vol.11 (1998)).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories by the technical guidelines. Because the result of the dominant lethal test using mice is negative (CERI Hazard Data (2002)), and the in vivo mutagenicity tests (several micronucleus tests using mice or rats) are negative as well (IARC 79 (2001)).
6 Carcinogenicity Not classified - - - - Based on the category of IARC (2001): 3, it was set as the outside of Category.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there were the increase of resorpted embryo, the reduction of brain weigt of embryo and the denaturation of tubule with dose not affecting maternal animal in rabbit organogenetic period administration test (DFGOT vol.11(1998)), and there were malformation od skeltal system, central nerve system and lung, adding to the dose-independent increase of the dead and reduction of weight of embryo with the dose not affecting to maternal animals in hamster (DFGOT vol.11 (1998)), it is classified into the Category 1B. There is the existing classifications of EU Annex 1: Repr.Cat.2;R61.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (thyroid, kidney), Category 2 (pituitary) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (thyroid, kidney)
H373: May cause damage to organs through prolonged or repeated exposure (pituitary) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is stated that the thyroid is the main target organ in mouse and especialy rat (DFGOT vol.11 (1998)). Since follicle cell hyperplasia, vacuolation of the thyroid gland, and the quantitative alteration of hormone, and vacuolation of tubular epithelial cells and edema were observed in kidney in rat with the given dose of the Category 1 guidance value range (DFGO vol.11 (1998) CERI hazard data (2002)), they were classified into Category 1 (thyroid gland and kidney). Moreover, since vacuolation of the pituicyte was observed with the given dose of the Category 2 guidance value range (DFGOT vol.11 (1998)), it was classified into Category 2 (pituitary).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48-hour EC50=13.3mg/L of Crustacea (Daphnia magna) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bio-accumulative (BCF=0.3 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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