GHS Classification Result

Chemical Name：Ethylenediamine
CAS：107-15-3

Result：
ID: 97
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is 34degC (c.c.) (ICSC, 2003) which is classified into Category 3. Classified into Class 3 and Class 8 (UN#1604) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 385degC (ICSC, 2003)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available. Corrosivity to metals remains uncertain, though classified as "corrosive substances" (as the classification based on UN Recommendations on the Transport of Dangerous Goods includes "skin corrosivity") (UN#1604).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 860mg/kg calculated from the testing data of rat LD50 (oral route) of 637mg/kg, 1,500mg/kg, 1,850mg/kg, (SIDS (2003)), and 1,160mg/kg, (ACGIH (7th 2001).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the testing data of rabbit LD50 (dermal route) of 560 mg/kg representing the lower of the two testing data, 560mg/kg (SIDS (2003)) and 657mg/kg (ACGIH (7th 2001)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on an LC50 value (8 hours) of over 29 mg/L (SIDS (2003)) calculated from testing data of rat (inhalation of vapour). The LC50 value (4 hours equivalent) is calculated at over 58 mg/L. The saturated vapour concentration under a saturated vapor pressure of 1.7kPa (25degC) (SIDS (2003)) stands at 17,000 ppm, which is converted into 41 mg/L (1 ppm=2.46 mg/m3 (25degC)). The LC50 value calculated (over 58 mg/L) exceeds the saturated vapour concentration. The substance, under the test conditions, is considered "mist" and hence not classified according to the criteria for "particles and mist."
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on rabbit temporary skin irritation tests (CICAD 15 (1999), SIDS (2003)): Exposure to ethylene diamine (for 6-12 minutes to 70% solution and for 24 hours to undiluted solution) causes dermal necrosis; the substance is considered "corrosive" to skin, though the results are not those of 4-hour application. Although classified into 1A-1C, as the 6-12 minute application of 70% solution suggests "corrosiveness," the substance is should be placed in Category 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on rabbit eye irritation tests (ACGIH (7th, 2001), CICAD 15 (1999), SIDS (2003): Administration of eye drops (undiluted solution) causes permanent damage to the eyes; the substance is considered to have "irreversible effects" on the eyes.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Based on the classification by the Japan Society for Occupational Health and the Japanese Society of Occupational Allergy (Respiratory Sensitizing Substances). Based on the description in the report on respiratory sensitization (CICAD 15 (1999), SIDS (2003)): Occupational exposure to ethylene diamine causes asthma; the substance is considered to cause "respiratory sensitization."
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the classification by the Japan Society for Occupational Health and the Japanese Society of Occupational Allergy (Skin Sensitizing Substances). Based on the description in the report on human skin sensitization (CICAD 15 (1999), SIDS (2003), MOE Risk Assessment vol. 3 (2004)) and guinea pig skin sensitization (CICAD 15 (1999), SIDS (2003)): Patch tests on dermatitis patients show positive, as do guinea pig skin sensitization tests. The substance is thus considered to cause "skin sensitization."
5 Germ cell mutagenicity Not classified - - - - Based on the negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo, and the absence of data on somatic cell mutagenicity tests in vivo, described in CERI Hazard Data 99-20 (1999), SIDS (2001).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 by ACGIH (2005).
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 1 (blood system, kidney, respiratory system) Danger H370: Causes damage to organs (blood system, kidney, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "tingling sensation on the face, mild irritation to the eyes and nasal mucosa," "corrosive damage to the eye/skin/respiratory tract, pulmonary edema (with inhalation of the vapor or mist)" (MOE Risk Assessment vol. 3 (2004)), "erythema, anuria, tachycardia, an increase in blood potassium concentrations, irritating cough associated with phlegm, gastralgia associated with diarrhea, vomiting, nephropathy associated with hemolysis and anuria, fatal hyperkalemia" (CERI Hazard Data 99-20 (2000)).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney, visual organs) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, visual organs) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "cloudy swelling of the liver/convoluted renal tubules," "cataract, conjunctivitis, retinal atrophy" (MOE Risk Assessment vol. 3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours LC50=3mg/L of the crustacea (Daphnia magna) (SIDS, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 94% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=-2.04 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information