Chemical Name:2,3-epoxypropan-1-ol
CAS:556-52-5
ID: | 98 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Category 4 because of its flash point: 72degC |
7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | This product including a ring with distortion (epoxides), and if this contacts metal salts etc., it is known to cause a very intense polymerization reaction. But there is no data, it cannot be classified. |
9 | Pyrophoric liquids | Not classified | - | - | - | - | Flash point: 415degC (ICSC (J), 1994) |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements). |
14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
It was set as Category 4 based on rat LD50 = 433mg/kg calculated from the three tests with rats (CERI Hazard Data (2002) and PATTY (5th, 2001)). | |
1 | Acute toxicity (Dermal) | Category 4 | Warning | H312: Harmful in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
It was set as Category 4 based on rabbit LD50= 1980mg/kg (ACGIH (2001), CERI Hazard Data (2002)). | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 | Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
The saturated vapor pressure concentration of this product is 1180ppm, and the 4 hour rat inhalation test (CERI Hazard Data (2002)) was conducted with steam. It was classified as Category 3 based on LC5 0= 580ppm based on the test. | |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
Since there are discriptions of moderate irritation on rabbits (ACGIH (2001), PATTY (5th, 2001)), it was classified as Category 2. | |
3 | Serious eye damage/eye irritation | Category 2A | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Although there were severe irritation and corneal disorders to eye of rabbit, it is not irreversible damage (ACGIH (2001), PATTY (5th, 2001)). So it was set as Category 2A. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
5 | Germ cell mutagenicity | Category 2 | Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 2 by the guidelines. Based on the facts that there are positive results from the somatic cell in vivo mutagenicity tests (the in vivo micronucleus and chromosome aberration tests in mice and rats) (CERI Hazard Data (2002), ACGIH (2001), DFGOT vol.20 (2003), PATTY (5th, 2001)), and that there is no positive result from germ cell in vivo genotoxicity tests. | |
6 | Carcinogenicity | Category 1B | Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 1B based on being classified into 2A in IARC (IARC77 (2000)) and into 2A in Japan Society for Occupational Health (Japan Society for Occupational Health recommendation (2004)), and into 2 in EU (EU-Annex 1 (2005)). | |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is no description about the toxicity to parental animals. However, there are descriptios of testicular atrophy (DFGOT vol. 20 (2003, ACGIH (2001)), decreased fertility (CERI Hazard Data Description (2002)), resorption, death and growth inhibition of embryo and fetus (IARC 77 (2000), (CERI hazard data (2002)). Therefore, it was classified into Category 2. | |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory system) | Danger | H370: Causes damage to organs (central nervous system, respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
It is mentioned, "effects on the central nervous system are reported, and irritant properties to upper respiratory organs are shown" in humans (CERI Hazard Data (2002)). There are reports of irritation to lungs, pneumonia, pulmonary emphysema in animals (ACGIH (2001)), and the dosages required for the development of these disorders are not mentioned, but it is estimated that they developed at dosages around the LD50 values (1.36mg/L, 1.78mg/L) or less. Such doses are within the range of the guidance values for Category 1. The substance was classified as Category 1 (central nervous system, respiratory system) based on these results. | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (central nervous system, liver, spleen) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, liver, spleen) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In rat and mouse, at the dosage within the guidance value range of Category 2 (ten to 100 mg/kg), it was classified into Category 2 (central nervous systems, liver, spleen) based on the descriptions of encephalic nerves demyelination, fiblrillization of spleen, and the coagulative necrosis of liver (CERI Hazard Data (2002)). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 96-hour EC50=53.3mg/L of algae (Selenastrum) (CERI Hazard Data, 2002). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since rapidly degrading (BOD: 85% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=-0.95 (PHYSPROP Database, 2005)). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
|
Definitions / Abbreviations |
|
Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |