GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Silver
CAS：7440-22-4
Result：
| ID: | 106 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-combustible (ISCS (1997)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not classified because of "Non-combustible" (ICSC, 1997) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not classified because of a non-combustible substance (ICSC, 1997) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Inorganic compounds containing no oxygen and halogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic substance |
| 16 | Corrosive to metals | Not classified | - | - | - | - | It does not corrod steel and aluminum from an ionization tendency. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | SPECIES: Rat ENDPOINT: LD50 VALUE: >5000 mg/kg REFERENCE SOURCE: DFGOTvol.19 (2003) |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | It was set as the outside of Category from the rat LD50: >2000mg/kg (HSDB (2003)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Since it is reported to be "Slightly irritating" on rabbits (IUCLID (2000)), it was classified as out of Category. |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
It was referred to as Category 2B from the statement of mild irritation by rabbit test / recovered in 48 hours (IUCLID (2000)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Classified as Category 1 because of the descriptions that powder exposure causes allergic contact dermatitis (ACGIH (2001)) and that contact to accessories containing silver produced allergic reactions (PATTY (5th, 2001)). |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | There are descriptions that carcinogenicity was not observed in the test in which powder was intramuscularly injected to rats (PATTY (5th, 2001)). And there is no carcinogenic evidence to humans (PATTY (5th, 2001), (HSDB (2003)). But there is no information of classification evaluation organizations such as IARC, so it was determined that it cannot be classified. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system) |
|
Danger | H370: Causes damage to organs (respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 1 (respiratory system). Based on the reports that lung disorders with pulmonary edema developed after exposure to heated metallic silver fumes for 4 hours (ACGIH (2001)), and that irritation to the airways develops after occupational exposure to the dust (ATSDR ToxFAQs (1997)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (eye), Category 1 (Inhalation: respiratory) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (eye) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
The argyrism (argyria) which is pigmentation in the skin and mucosa is produced by occupational exposure to powders (ACGIH (2001)) (PATTY (5th, 2001)), but as the description of dysfunction of decreased night vision (ATSDR ToxFAQs (1997)), it was classified into Category 1 (eye). It was classified into Category 1 (respirator: inhalation) with the description that it became bronchitis by deposition to the lungs by prolonged inhalation of a dust (PATTY (5th, 2001))(HSDB (2003)) . |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Solid (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Insufficient data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |