GHS Classification Result

Chemical Name：Glutaraldehyde
CAS：111-30-8

Result：
ID: 107
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 4 because of its flash point: 72degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not classified - - - - Not combustible (indicated as ICSC (2000).) The ignition points is 225 degC (CERI Hazard Data (2000)).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC, 2000)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 149 mg/kg (calculated from 23 of LD50 values)
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on the calculation value of 1100mg/kg calculated from 6 rabbit LD50 values.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified as Category 1 based on 23.5ppm, the lower value of the two LC50. Since LC50 was less than 90% of saturated vapor pressure concentration, gaseous (ppm) Category was used.
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of ENDPOINT: LC50; VALUE (lower): 0.48 mg/L
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the skin irritation test on rabbits, not only erythema and dropsy but necrosis are found all six rabbits with concentrations of 10% or more (NICNAS (1994)). Furthermore, since it is described to be "highly irritating" after 1-hour exposure and "corrosive" after 4-hour exposure in another study (DFGOT vol.8 (1997)), it was classified as Category 1A-1C. In addition, there are a large number of reports on skin irritations and dermatitis from occupational exposure on humans, especially among hospital related persons (NICNAS (1994)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		In eye irritation test with rabbit, the severe and continuous stimulus accompanied by a necrosis to the conjunctival was acknowledged, and it continued for two weeks with the half of the animals (NICNAS (1994)). Moreover, in another study, corneal opacity got worse three days afterward (NICNAS (1994)). It was set as Category 1 based on these statement. In addition, the example of exposure by the accident which was accepted conjunctiva inflammation, a palpebral edema, heliophobe, etc. by humans is reported (ACGIH (2001)).
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		There are several reports that humans showed rhinitis, asthma with breathing difficulties, or asthma-like symptoms exposed by this substance (NICNAS (1994)) and a report that concludes that this product caused an occupational asthma based on a bronchial hypersensitive test (ACGIH (2001)). Moreover, the Japan Society for Occupational Health (JSOH advice (2005)) and the Japanese Occupational and Environmental Allergology Society (ALGY society, list of (sensitizing) substances (proposal), p95) listed this as a respiratory tract sensitization and a sensitizing chemical substance, respectively. Therefore, we classified this as Category 1. In addition, animal testing cannot confirm positive findings (NICNAS (1994)).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There are several reports that health care workers, especially in hospitals and clinics, develop contact dermatitis and that positive reactions are confirmed by patch tests and all are believed to be allergic reactions (NICNAS (1994), DFGOT vol.8 (1997)). In addition, every skin sensitization test with various kinds of methods using guinea pigs, i.e. "Maximization test", "modified Magnusson-Kligman test" and "Buehler test" resulted positive (NICNAS (1994), ECETOCTR77 (1999)). Skin sensitization was classified into Category 1 based on the above information.
5 Germ cell mutagenicity Not classified - - - - Dominant lethal tests in mice (in vivo multi-generation mutagenicity tests), micronucleus tests using mouse peripheral blood cells and chromosome aberration tests using rat bone-marrow cells (in vivo mutagenicity tests using somatic cells) have been done. Because all the results of these tests are negative (NICNAS (1994)), the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - - Based on the classification of A4 (1997) by ACGIH, it was set as the outside of Category. There is no statement of the classification by other evaluation organizations.
7 Reproductive toxicity Not classified - - - - As the result of rabbit and mouse oral administration in organogenetic period, it is observed no adverse effects for fetal development including teratogenesis (NICNAS (1994), DFGOT vol.8(1997)). Furthermore, since although weight loss was observed in mother animal and the born child, the adverse effects on reproduction in two-generation administration to rats were not observed (NTP TR490 (1999)), it was out of the Category.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		The substance was classified as Category 1 (central nervous system). Because central symptoms, such as inertia, delay in righting reflex and decrease of motor ability, were observed after a single oral exposure of 50 - 200mg/kg or inhalation exposure (fumes) of 10.6 - 42.7ppm in rats (NICNAS (1994)). The substance was classified as Category 3 (airway irritant). Because there is a report of an human epidemiological study indicating a clear relationship between irritation of the upper airway and occupational (hospital) environmental concentration (DFGOT vol.8(1997)), and there are reports of symptoms associated with airway irritation, such as low respiratory rate and coagulation of original squamous epithelium as the results from inhalation tests in rats and mice (NICNAS (1994), ACGIH (2001), DFGOT vol.8 (1997)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory tract) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory tract) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the test which carried out inhalation exposure to rat and mouse for 13 weeks, pathological changes, such as a necrosis and inflammation in the respiratory tract(the nose, the larynx and tracheal gill) are observed(NTP TR490 (1999)). Moreover, change of the upper airways, such as vestibular neutrophilic infiltrate, destruction and fusion of turbinate are observed in another similar test, but histologic changes are not observed in any parts other than respiratory tract (ACGIH (2001)). These change was observed at 0.5-1ppm, since there are fatal cases it is considered as significant toxic changes, and it was classified into Category 1 (respiratory tract) as compared with the guidance value. In addition, such effect on the respiratory tract is not observed in oral administration (NICNAS (1994)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour LC50=0.35mg/L of Crustacea (Daphnia magna), and others (SIDS, 1998).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (the decomposition of TOC: 86% (Existing Chemicals Safety Check Data)), and supposed less bio-accumulative (log Kow=-0.18 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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