Chemical Name：2-Ethoxyethyl acetate; Ethylene glycol monoethyl ether acetate
CAS：111-15-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	The flash point is 51.1degC (c.c.) (ICSC, 2003) which is classified into Category 3. Classified into Class 3 and Packing Group III (UN#1172) (UN Recommendations on the Transport of Dangerous Goods)
7	Flammable solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Not classified	-	-	-	-	Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 379degC (ICSC, 2003)
10	Pyrophoric solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14	Oxidizing solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Not classified	-	-	-	-	Classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#1172)

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the testing data of rat LD50 (oral route) of 2,700mg/kg (MOE Risk Assessment Vol. 2, 2003).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Because the LC50 value (4 hours) of 24.2mg/L (4,470ppm), calculated from the testing data of rat LC50 (8 hour inhalation exposure) of 12.1mg/L (MOE Risk Assessment vol. 2 (2003)), exceeded the saturated vapour concentration (3,080ppm) under a saturated vapour pressure of 2.34mmHg (25degC), the substance was hence not classified based on standard values of mist.
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 2001-68 (2002)): The results of 24-hour application suggest "mild irritation" of the skin, though those of 4-hour application are not available.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Based on the evidence of "mild irritation" from rabbit eye irritation tests (CERI-NITE Hazard Data 2001-68 (2002)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo, described in CERI Hazard Data 2001-68 (2002) and NTP DB (Access on December 2005).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the description in the report on rat teratogenicity studies (CERI Hazard Data 2001-68 (2002)): Visceral malformations (cardiac, umbilical cord malformations) and skeletal malformation (symphysis, undulated ribs) are observed in the embryo at dose levels not toxic to the dam.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Based on the evidence from animal studies including adverse effects on the testes and kidneys. The amount of exposure, however, is not applicable to the dosage that can be classified; the toxicity within the range of the classification is unknown.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available