GHS Classification Result

Chemical Name：Ethane, 2,2-dichloro-1,1,1-trifluoro-
CAS：306-83-2

Result：
ID: 132
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible, Flash point: none (Non-hazardrous Substance) (Solvent Pocket Book, 1997), Limits of flammability: Non-flammable (PATTY, 5th, 2001)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Nonflammable and no flash point (non-dangerous object) (pocket book books (1997)). Limits of flammability: Nonflammable (PATTY (5th, 2001))
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - With nonflammable and no flash point (non-dangerous object) (solvent pocket book (1997)). Limits of flammability: Nonflammable (PATTY(5th, 2001))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine and fluorine (but not oxygen) and these elements are chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gas substances are not available. Boiling point: 27.6degC (NICNAS, 1996)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Since the minimum lethal doses was presumed to be 9000 mg/kg by the rat (NICNAS (1999)), it was set as the outside of Category.
1 Acute toxicity （Dermal） Not classified - - - - Since mortality was not observed in rat and rabbit at 2000mg/kg (NICNAS (1999)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Rat LC50 (4-hour exposure value) = 35000, 32000ppm (NICNAS (1999)). Since all LC50 values far exceed (by 6 - 7 fold) the cut-off value of Category 4, it was classified as out of Category.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - As a result of the skin irritation study on rabbits under the OECD Guidelines, there was no erythema and dropsy, and skin irritation was not found (NICNAS (1999)), therefore, it was classified as out of Category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Although mild to moderate conjunctival irritation and mild corneal clouding are mainly observed by applying concentrate solution of this material or 50% solution to rabbit eye (NICNAS (1999)), it recovered completely within three to seven days (EHC 123 (1992)). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category because the skin sensitization test using guinea pigs found no skin sensitization as intradermal injection after sensitization treatment induced no allergic reactions (NICNAS (1999)).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories because the results of the chromosome aberration test using rat lymphocytes and the micronucleus test using mouse erythrocytes (both are in vivo mutagenicity tests) are negative.
6 Carcinogenicity Classification not possible - - - - In two years inhalation study to rats, there was no generating of malignant tumor considered to be originated in exposure. But significant or dose dependent increases of hepatic adenoma, bile duct fibroid tumor, leydig cell adenoma, and acinar cell adenoma of pancreas were observed (NICNAS (1999)). However, except for the classification (3B) by DFG, the classification of other evaluation organizations was not made. So it was determined "It cannot be classified."
7 Reproductive toxicity Not classified - - - - There is no effect on survival and generation of the child with organogenetic period exposure in rats and rabbits (NICNAS (1999), ECETOC JACC (2005)). The effects to reproductive functions or potential are not observed in rat two-generatioin exposure test (since pre-mating period to pregnancy and lactation period of F0, since pre-mating to pregnancy and lactation period of F1) (NICNAS (1999)). Moreover, although a metabolite is detected in milk or newborn blood with peripatum exposure in rat and ape, effects on lactation is not observed, either (NICNAS (1999)). As mentioned above, it was out of the Category.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, liver), Category 2 (heart) Danger
Warning 		H370: Causes damage to organs (central nervous system, liver)
H371: May cause damage to organs (heart) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. 		Central symptoms, such as dizziness and headaches are reported to 40 laborers who received exposure of this product by exploded industrial cooler (NICNAS (1999)). Moreover, there is the report that the workers engaged in dry cleaning received exposure of the solvent including the this product and hepatic function test results rose, and showing the symptoms of acute hepatitis (virus infection is negated) (ECETOC JACC (2005)). It was classified into Category 1 (the central nervous system, liver) based on these results. In addition, for the effects to the liver, liver function tests raised, liver degeneration, and hepatic necrosis are observed in inhalation single exposure in guinea pig (NICNAS (1999)). On the other hand, there is the example of report of developed coronary artery diseases in the human to whom fluorocarbon was exposed (HSDB (2003)), and cardiac inadequacy as short-term exposure effects was decribed in ICSC (1998). The test result that adrenergic hypersensitivity is caused to the heart by exposure of this product in dog is obtained (NICNAS (1999)). It was classified into Category 2 (heart) based on these results.
9 Specific target organ toxicity - Repeated exposure Category 1 (liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the many reports that the liver function test value was elevated or hepatic disorder was affected by occupational repeated exposure, it was classified into Category 1 (liver) (NICNAS (1999), ECETOC JACC (2005)). In addition, when a repeated dose is carried out to animals for two to 13 weeks, the toxic effects on the liver is also observed (NICNAS (1999)), but it is restricted to high levels of exposure over the range of the guidance value.
10 Aspiration hazard Classification not possible - - - - Insufficient data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48-hour EC50=17mg/L of Crustacea (Daphnia magna), and others (CICAD23, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and not rapidly degrading (BOD: 6% (existing chemical safety inspections data)), though less bio-accumulative (BCF=36 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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