GHS Classification Result

Chemical Name：Diuron
CAS：330-54-1

Result：
ID: 133
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (HSDB, 2005)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (HSDB, 2005)
11 Self-heating substances and mixtures Not classified - - - - Not combustible. (HSDB (2005))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine and these elements are chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although HSDB (2005) has the description "it has no corrosiveness," the test suitable for a solids material is not established.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Category 5 based on SPECIES: Rat(male); ENDPOINT: LD50; VALUE: 4990mg/kg; REFERENCE SOURCE: Agricultural Chemicals Registration Data(1996)
1 Acute toxicity （Dermal） Not classified - - - - Rat LD50 >2000mg/kg of Agricultural Chemical Registration Data (1996) corresponds to Category 5 or outside of Category. But rat LD50 >5g/kg of RTECS (2004) corresponded to outside of Category, it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - This product has very low vapor pressure (less than 0.00115mPa at 25degC), and since vapor exposure was considered to be difficult, it was out of classification.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - According to Agricultural Chemical Registration Data (1996) of the rat LC50 >5.0mg/L, it was set as the outside of Category.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Agricultural Chemical Registration Data (1996) Since slight erythema was seen on the healthy skin of three among ten in the primary skin irritation test on guinea pigs, it was classified as Category 3. ACGIH (7th, 2001) and ACGIH-TLV (2005) report that there are skin irritations.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Although very slight redness, swelling, and a secretion were acknowledged in the conjunctiva by the eye primary irritation examination of the rabbit (Agricultural Chemical Registration Data (1996)), symptom was recovered by the 4th day of application. So it was set as Category 2B. In addition, it is supposed that there is eye irritation (ACGIH (7th, 2001) and ACGIH-TLV (2005)).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category because the skin sensitization test using guinea pigs found no skin sensitization in Agricultural Chemical Registration Data (1996).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories because of the negative result of the in vivo mutagenicity test using somatic cells (the chromosome aberration test in bone-marrow cells) in Agricultural Chemical Registration Data (1996).
6 Carcinogenicity Not classified - - - - In rat and mouse carcinogenic examination in Agricultural Chemical Registration Data (1996), the neoplastic lesions relevant to this substance was not observed. So it was set as the outside of Category. In addition, it is classified into A4 (corresponding to out of Category) according to ACGIH-TLV (2005).
7 Reproductive toxicity Not classified - - - - In the three-generation reproductive toxicity test of the rat, and teratogenicity test of rat and rabbit (Agricultural Chemical Registration Data (1996)), there was no obvious effect involved with the material. So it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the descriptions that the red secreted material was observed in nose or mouth in the acute inhalation toxicity study in rat in Agricultural Chemical Registration Data (1996), and that this product had weak irritation to the skin and eye. So it was classified into Category 3 (respiratory irritant). In addition, it has respiratory irritant in ACGIH (7th, 2001) and ACGIH-TLV (2005).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		The effects on the blood was observed in the repeated exposure test (feeding administration) in the dogs and rats of Agricultural Chemical Registration Data (2005) (especially reduction of red corpuscle parameters, such as a red blood cells and hemoglobin concentration). It was classified into Category 2 (blood) due to comparison with the dosage in which toxicity appeared and the guidance value. (Although other effects on the kidney, liver, etc. were also observed, it was not considered serious effect and they were not included in target organs.)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72-hour EbC50=0.013mg/L of algae (Green algae) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bioaccumulative (BCF=14 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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