GHS Classification Result

Chemical Name:2,4-Dichlorophenoxyacetic acid
CAS:94-75-7

Result:
ID: 134
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (1994))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 1994)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (1994))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine and these elements are chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Corrosive to metals (HSDB, 2005)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
SPECIES: Rat ENDPOINT: LD50 VALUE: 420 mg/kg REFERENCE SOURCE: Agricultural Chemical Registration Data (1992)
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Although there was no data, it was set as Category 5 from rat LD50 value (>2000mg/kg: Agricultural Chemical Registration Data, 1992) of the sodium salt of this substance. In addition, the range of Category 5 was 2000
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
There is no this product data. But was set as Category 4 based on that rat LC50 value of sodium salt and dimethylamine salt are ,respectively, >0.64mg/L and >3.7mg/L (no death case in 2.7mg/L, 2 death cases in 3.7mg/L)(all being 4-hour exposure)(Agricultural Chemical Registration Data, 1992).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Since mild irritation was seen in the rabbit skin irritation tests with sodium salts of this product (Agricultural Chemical Registration Data, 1985), it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Since mild irritation was seen in the test for rabbit eye irritation using the sodium salts of this product (Agricultural Chemical Registration Data, 1985), it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Classified as out of category because the guinea pig Maximization test using the sodium salt of this substance showed negative (Agricultural Chemical Registration Data, 1990).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories because the micronucleus test in mouse bone-marrow was negative (Agricultural Chemical Registration Data, 1995). In addition, the in vitro mutagenicity tests (the Ames test and chromosome aberration test) were also negative (Agricultural Chemical Registration Data, 1992).
6 Carcinogenicity Not classified - - - - Since carcinogenicity was not observed in mice and the rat (Agricultural Chemical Registration Data, 1998), it was set as the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In two generations fecundity study of rat , there was reductions of survival rate of child animals in the dose which have the effect to dam animals (Agricultural Chemical Registration Data, 1998). So it was considered as in the Category 2. In addition, there was no teratogenicity in the rat and rabbit (Agricultural Chemical Registration Data, 1998).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In the feeding administration tests for 90 days in rat, the effects were observed in the liver (hepatocellular hypertrophy) at 100mg/kg or more, and the effects on an eye (cataract) were observed at 300mg/kg, and in the feeding administration tests for 90 days of dog, the effect in the liver (chronic active inflammations) was observed at 7.5mg/kg/day (Agricultural Chemical Registration Data, 1998). Althogh the effects on the liver was within the upper limit of guidance value range of Category 2, it was observed within the guidance value of Category 1 with the dog, and in chronic toxicity and carcinogenicity merging study for two years using rat, the effects on eye (retinal degeneration) and the liver (hepatocytic hypertrophy, eosinophila) and the lung (inflammation) were observed at 150mg/kg (Agricultural Chemical Registration Data, 1998), since all were outside guidance range of Category 2, and findings of the liver in dogs was observed to be one of four examples (males and females) and the extent was also moderate, it was not judged to be the serious toxic effect which endorses the Category 1, it was classified into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=0.373mg/L of fishes (King salmon) (EHC84, 1989).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (BOD: 0% (existing chemical safety inspections data)), though less bioaccumulative (BCF<10.1(existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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