GHS Classification Result

Chemical Name：1,2-Dichloropropane
CAS：78-87-5

Result：
ID: 136
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is 16degC (c.c.) (ICSC, 2000) and the boiling point is 96degC, which is classified into Category 2. Classified into Class 3 and Packing Group II (UN#1279) (UN Recommendations on the Transport of Dangerous Goods)
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 557degC (ICSC, 2000)
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Class 3 (UN Recommendations on the Transport of Dangerous Goods, UN#1279)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the testing data of rat LD50 (oral route) of 1,900mg/kg (EHC 146 (1993)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the testing data of rabbit LD50 (dermal route) of 10,115mg/kg (DFGOT vol. 9 (1998)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on the LC50 value of 35mg/L (7,600ppm), calculated from the testing data of rat LC50 (10-hour inhalation of vapour) of 14 mg/L (PATTY 5th (2001)), was lower than 90% of the saturated vapour concentration (70,000ppm) under a saturated vapour pressure of 7.1kPa (25degC) (HSDB, 2005), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the evidence of "mild irritation" from rabbit skin irritation tests (CERI-NITE Hazard Assessment No.39 (2005)) and human reports (MOE Risk Assessment vol.2 (2003)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the evidence of "moderate irritation" from rabbit eye irritation tests (CERI-NITE Hazard Assessment No.39 (2005)) and human reports (MOE Risk Assessment vol.2 (2003)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description in the report on two human symptoms (EHC 146 (1993)): The substance causes skin sensitization.
5 Germ cell mutagenicity Not classified - - - - Based on negative data on multi-generation mutagenicity tests (rat dominant lethal tests) and the absence of data on germ/somatic cell mutagenicity tests in vivo, described in CERI-NITE Hazard Assessment No.39 (2004).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 by ACGIH (2001) and Group 3 by IARC (1999).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in ATSDR (1989): Degeneration is observed in the testes, including impaired spermatogenic ability and an increase in abnormal sperms.
8 Specific target organ toxicity - Single exposure Category 1 (liver, blood, kidney), Category 3 (respiratory tract irritation, narcotic effects) Danger
Warning 		H370: Causes damage to organs (liver, blood, kidney)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "hepatotoxicity associated with portal hypertension, hepatic necrosis, hemolytic anemia, thrombosis" (CERI Hazard Data 98-16 (1999)), "acute effects on the kidneys, tubulonecrosis" (EHC 146 (1993)) "a sense of fatigue due probably to central nervous system depression" (ATSDR (1989)), and the evidence from animal studies including "respiratory irritation" (ACGIH (7th, 2001)), "dyspnea, a decrease in mobility, coma" (CERI-NITE Hazard Assessment No.39 (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, liver, blood system), Category 2 (respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (kidney, liver, blood system)
H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "severe nephropathy (an increase in creatinine and urea nitrogen concentrations), acute hepatopathy (an increase in AST, ALT and bilirubin levels), hemolytic anemia, thrombosis, tubulonecrosis" (CERI Hazard Data 98-16 (1999)), and the evidence from animal studies including "olfactory epithelial degeneration" (CERI-NITE Hazard Assessment No.39 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48 hours EC50=13600microg/L of the crustacea (Ceriodaphnia) (MOE Risk Assessment vol. 2 (2003) and others.).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 3 and the potential was low (BCF=6.9(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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