GHS Classification Result

Chemical Name:p-Dichlorobenzene
CAS:106-46-7

Result:
ID: 140
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as "flammable" by ICSC (2004).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available - melting point: 53degC (ICSC, 2004), test temperature: 140degC
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LD50 (oral route) value of 2,512mg/kg representing the lower of the two testing data, 2,512mg/kg (NICNAS (2000)) and 2,515mg/kg (DFGOT vol. 4 (1992)).
1 Acute toxicity (Dermal) Classification not possible - - - - Insufficient data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Because the rat LC50 (4-hour inhalation) value of 5.07mg/L (equivalent to 845ppm) (CERI-NITE Hazard Assessment No.76 (2005)) was higher than 110% of the saturated vapour concentration (790ppm, 20degC), the substance was considered as "dust exposure containing vapour" and was classified based on the dust classification.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (4-hour application) performed in accordance with OECD Guidelines (CERI-NITE Hazard Assessment No.76 (2005)): Mildly irritating.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description in the report on rabbit eye irritation tests performed in accordance with OECD Guidelines (CERI-NITE Hazard Assessment No.76 (2005)): Redness and edema of the conjunctiva are observed in one out of three specimens, both of which disappear after 72 hours of exposure; mild eye irritation is observed, with no effects on the iris and cornea. The substance is considered "mildly irritating" to the eyes.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the description in CERI-NITE Hazard Assessment No.76 (2005) - Nine out of 24 specimens (Score: 1), four out of 24 specimens (Score: 2) and one out of 24 specimens (Score: 3) (all scored based on the maximization method). The substance is considered to cause skin sensitization.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), and the absence of data on germ cell genotoxicity tests in vivo, described in EU-RAR No.48 (2004) and IARC 73 (1999).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category A3 by ACGIH (2005), Category R by NTP (2005), Category 3 by EU (2004) and 2B by IARC (1999).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in the report on two-generation reproductive toxicity tests (oral route) (EU-RAR No.48 (2004), CERI-NITE Hazard Assessment No.76 (2005)): A decrease in the number and body weight of alive newborns is observed at dosing levels not toxic to parental animals.
8 Specific target organ toxicity - Single exposure Category 1 (blood system, liver) Danger H370: Causes damage to organs (blood system, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence including "hypochromia, microcytic anemia, methemoglobinuria" (CERI Hazard Data 96-47 (1998)), "jaundice, hemolytic anemia, methemoglobinuria" (CERI-NITE Hazard Assessment No.76 (2005).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, liver, nervous system), Category 2 (kidney) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, liver, nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (kidney)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "pulmonary granulomatosis, hepatic atrophy/cirrhosis, ataxia, speech disorder, tremor in the fingers, an increase of muscular reflexes" (CERI Hazard Data 96-47 (1998)) and the evidence from animal studies including "pulmonary interstitial edema, congestion, alveolar hemorrhage, cloudy swelling in the liver, focal necrosis, cirrhosis, an increase in the kidney weight, hyaline droplet accumulation in the renal tubular epithelium" (CERI Hazard Data 96-47 (1998)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48 hours EC50=0.7mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2005) and others.).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since there was rapidly degrading (28 days decomposition (the OECD testing guideline 301D): 67% (EU-RAR, 2004)), and bio-accumulation was low (BCF=190 (Existing Chemical Safety Inspections Data)), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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